Abstract: Objective To investigate the changes in brain regional homogeneity in first-onset major depressive disorders
(MDDs) using resting-state functional magnetic resonance imaging (fMRI). Methods Eighteen patients with first-onset MDDs
and twenty gender- and age-matched healthy controls underwent resting-state fMRI scans to compare the regional
homogeneities of the brain regions. Results Compared with the normal controls, the patients with MDDs showed significantly
decreased regional homogeneity in the left posterior cingulated gyrus, bilateral inferior temporal gyrus, bilateral superior
temporal gyrus, left inferior frontal gyrus, left hippocampa gyrus, left posterior central gyrus, left angular gyrus, right
amygdala, right orbital frontal gyrus, right supplementary motor area, and right cerebellar lobe. Conclusion Patients with
first-onset MDDs have dysfunctions in the brain regions closed related with cognition and emotional control.