Abstract: Cognitive impairment in diabetes (CID) is a severe chronic complication of diabetes mellitus, and its pathogenesis
has not yet been fully understood. Increasing evidence has shown that the distribution and expression of
N-methyl-D-aspartame receptor (NMDAR) and subunits NR2A and NR2B, which all participated in the development of the
central nervous system and formation of learning and memory, are correlated with the occurrence and development of CID.