Abstract: Objective To compare the differences in the anterior chamber depth (ACD) measured by anterior segment optical
coherence tomography (AS-OCT) and ultrasound biomicroscopy (UBM). Methods All studies pertaining to ACD measured by
AS-OCT and UBM were collected from online databases. The assessment of methodological quality and data extraction from
the included studies were performed independently by two reviewers for meta-analysis. Results Eight studies involving 710
eyes were included in the analysis. The difference of ACD measurements between AS-OCT and UBM was not statistically
significant in the overall patients included for analysis (SMD=0.19, 95% CI ［0.00, 0.39］) or in the patients with primary
angle-closed glaucoma (SMD=0.02，95% CI［-0.04，0.19］). Conclusion The ACD measurements do not differ significantly
between AS-OCT and UBM. Due to the relatively small number of the included studies and the patients involved, this
conclusion needs further confirmation by high-quality studies involving larger sample sizes.