Abstract: Objective To investigate the association between rs185983011 single-nucleotide polymorphisms (SNP) of
apolipoprotein B mRNA editing enzyme catalyitc polypeptide-like 3G (APOBEC3G) and the susceptibility to chronic hepatitis
B. Methods The blood samples were collected from 186 healthy subjects and 159 patients with chronic hepatitis B. The
rs185983011 SNP was detected and genotyped by sequencing with Sanger’s method to analyze the relationship between
rs185983011 SNP and chronic hepatitis B. Results Only C/C and C/T genotypes of the alleles of rs185983011 SNP were found in
the tested subjects, and the C/C genotype was predominant (97.7% ). The distribution frequencies of rs185983011 SNP
genotypes and alleles showed no significant difference between healthy subjects and patients with chronic hepatitis B (P>0.05).
Conclusion The predominant genotype of rs185983011 SNP of APOBEC3G is C/C in the tested subjects, and rs185983011 SNP
does not appear to associate with the susceptibility to chronic hepatitis B.