Abstract: Objective To evaluate the association of sperm mobility parameters assessed by computer-assisted sperm analysis
(CASA) with the rates of normal fertilization, oocyte cleavage and excellent embryos in in vitro fertilization (IVF) cycles.
Methods A total of 288 infertile women undergoing IVF cycles patients were divided into two groups according to the normal
fertilization rate (≥50% and <50%), cleavage rate (≥90% and <90%), or excellent embryo rates (≥50% and <50%). The means
of the sperm motility parameters analyzed by CASA twice before oocyte retrieval were recorded and analyzed using t-test in
relation to the rates of normal fertilization, cleavage and excellent embryos in IVF cycles. Results The mean curvilinear velocity
(VCL), average path velocity (VAP), and amplitude of lateral head displacement (ALH) were significantly higher in women
with a normal fertilization rate of ≥50% than in those with a normal fertilization rate of <50% (P<0.05). Women with an oocyte
cleavage rate of ≥90% had significantly higher VCL and VAP than those with a cleavage rate of <90% (P<0.05). The VCL,
straight line velocity (VSL), VAP, linearity, straightness, wobble coefficient, ALH, or beat-cross frequency showed no significant
differences between women with excellent embryo rates of ≥50% and <50% (P>0.05). Conclusion The sperm motility
parameters assessed using CASA are associated with normal fertilization and oocyte cleavage rates but not with excellent
embryo rate in IVF cycles.