Abstract: Objective To evaluate the clinical therapeutic effect of three-dimensional conformal hypofractionated high-dose radiotherapy combined with chemotherapy for non-small-cell lung cancer (NSCLC).Methods The combined treatment was carried out in 63 cases of NSCLC and the short-term effects, the patients’ survival rate and complications were observed.Results Local control of tumor growth was achieved in 79.1% of the patients and the survival rates of 1, 3, and 5 years were 65.2%, 23.2%, and 10.4%, respectively. The median actual survival of the patients was 14 months. Late radiation pneumonitis (grade 3 or 4) and oesophagitis occurred in 9.5% and 4.8% of the patients, respectively.Conclusion s Three-dimensional conformal hypofractionated high-dose radiotherapy combined with chemotherapy can be an effective and practical approach to treat NSCLC, but local recurrence remains the major factor of treatment failure.