Effect of early nutritional support on plasma superoxide dismutase, malondialdehyde and nitric oxide in rats with burns in a hot and humid environment

Abstract

Abstract: Objective To observe the changes of plasma superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) in rats with combined stress of burn injury and hot and humid environment. Methods The rats with superficial second-degree scald were subjected to intragastric administration of double-distilled water for one week (control group) or treated with ascorbic acid and L-arginine mixed with α-Tocopherol for one week (treatment group). All the rats were exposed to the same hot and humid environment of Td 37±0.5 ℃ with relative humidity of 65%±5% for 1-2 h. Observation was performed at 1, 2, 4, and 10 h after the heat exposure, respectively. Results SOD and MDA changes were significantly different between the two groups (P<0.01, P<0.05). In the control group, NO levels at 1 h were significantly different from those measured at 2 and 6 h after the exposure (P<0.01, P<0.05). Conclusion Early nutritional support can significantly reduce the stress organ injuries, and prevent complications following injury in a hot and humid environment.

CLC Number:

R459.3

WANG Ying¹, LI Ya-jie¹, ZHAI Hui-min², XU Cai-xia¹, LUO Bing-de³. Effect of early nutritional support on plasma superoxide dismutase, malondialdehyde and nitric oxide in rats with burns in a hot and humid environment[J]. Journal of Southern Medical University, 2005, 25(01): 93-95.

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