南方医科大学学报

南方医科大学学报 ›› 2019, Vol. 39 ›› Issue (09): 1118-.doi: 10.12122/j.issn.1673-4254.2019.09.19

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血清25（OH）维生素D与非酒精性脂肪肝肝脏脂肪含量的相关性

付丽坤，崔红梅，卢坤玲，邹春燕，纪桂贤，李莉，李京龙，盛丽娜，谢长顺   

  • 出版日期:2019-09-20 发布日期:2019-09-20

Correlation between serum 25(OH) vitamin D and liver fat content in nonalcoholic fatty liver disease

  • Online:2019-09-20 Published:2019-09-20

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摘要： 目的探讨血清25（OH）维生素D与非酒精性脂肪肝（NAFLD）肝内脂肪含量的关系。方法选取2017 年6~8 月我院健 康体检及住院的NAFLD者120例，将患者分为血清25（OH）维生素D>75 nmol/L（n=25，A组），50~75 nmol/L（n=35，B组），25~ 50 nmol/L（n=32，C组），<25 nmol/L（n=28，D组）。采用ELISA法检测血清25（OH）维生素D浓度，应用T1WI同/反相位测定肝内 脂肪含量。全部计量资料用均数±标准差表示，多组间比较采用方差分析及Spearman 相关分析，两两比较采用LSD-t 检验。 P<0.05表示差异有统计学意义。结果B组（28.66±6.45）%及C组（38.74±11.47）%肝脏脂肪含量高于A组（22.79±6.10）%，但差 异无统计学意义（P>0.05）。D组（54.79±5.28）%肝脏脂肪含量高于A、B、C三组，差异有统计学意义（P>0.05）。随着血清25 （OH）维生素D含量减低，肝脏脂肪含量升高，呈负相关关系（P<0.05，r=-0.125）。结论血清25（OH）维生素D越低，肝脏脂肪含 量越高，血清25（OH）维生素D有望成为NAFLD的预测指标。

Abstract: Objective To investigate the relationship between serum 25(OH) vitamin D and liver fat content in nonalcoholic fatty liver disease (NAFLD). Methods A total of 120 patients with NAFLD admitted in our hospital between June and August, 2017 were enrolled and divided into 4 groups with different serum 25 (OH) vitamin D levels: >75 nmol/L (group A, n=25), 50-75 nmol/L (group B, n=35), 25-50 nmol/L (group C, n=32), and <25 nmol/L (group D, n=28). For all the patients, serum 25 (OH) vitamin D level was measured by ELISA, and liver fat content was determined using in-phase opposed-phase T1WI sequences. The measurement data were compared among the 4 groups to assess the association between serum 25(OH) vitamin D level and liver fat content. Results The liver fat content appeared to be higher in group B (28.66±6.45%) and group C (38.74±11.47%) than in group A (22.79 ± 6.10%), but the difference was not statistically significant (P>0.05); the liver fat content in group D (54.79 ± 5.28%) was significantly higher than that in the other 3 groups (P>0.05). Liver fat content increased significantly as serum 25(OH) vitamin D level decreased, showing an inverse correlation between them in these patients (P<0.05, r=-0.125). Conclusion In patients with NAFLD, a decreased serum 25(OH) vitamin D level is associated with an increased liver fat content, suggesting the value of serum 25(OH) vitamin D as a predictor of NAFLD.