[1]付丽坤,崔红梅,卢坤玲,等.血清25(OH)维生素D与非酒精性脂肪肝肝脏脂肪含量的相关性[J].南方医科大学学报,2019,(09):1118.[doi:10.12122/j.issn.1673-4254.2019.09.19]
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血清25(OH)维生素D与非酒精性脂肪肝肝脏脂肪含量的相关性()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2019年09期
页码:
1118
栏目:
出版日期:
2019-09-15

文章信息/Info

Title:
Correlation between serum 25(OH) vitamin D and liver fat content in nonalcoholic fatty liver disease
作者:
付丽坤崔红梅卢坤玲邹春燕纪桂贤李莉李京龙盛丽娜谢长顺
关键词:
血清25(OH)维生素D肝内脂肪含量非酒精性脂肪性肝病
Keywords:
serum 25 (OH) vitamin D liver fat content nonalcoholic fatty liver disease
DOI:
10.12122/j.issn.1673-4254.2019.09.19
摘要:
目的探讨血清25(OH)维生素D与非酒精性脂肪肝(NAFLD)肝内脂肪含量的关系。方法选取2017 年6~8 月我院健 康体检及住院的NAFLD者120例,将患者分为血清25(OH)维生素D>75 nmol/L(n=25,A组),50~75 nmol/L(n=35,B组),25~ 50 nmol/L(n=32,C组),<25 nmol/L(n=28,D组)。采用ELISA法检测血清25(OH)维生素D浓度,应用T1WI同/反相位测定肝内 脂肪含量。全部计量资料用均数±标准差表示,多组间比较采用方差分析及Spearman 相关分析,两两比较采用LSD-t 检验。 P<0.05表示差异有统计学意义。结果B组(28.66±6.45)%及C组(38.74±11.47)%肝脏脂肪含量高于A组(22.79±6.10)%,但差 异无统计学意义(P>0.05)。D组(54.79±5.28)%肝脏脂肪含量高于A、B、C三组,差异有统计学意义(P>0.05)。随着血清25 (OH)维生素D含量减低,肝脏脂肪含量升高,呈负相关关系(P<0.05,r=-0.125)。结论血清25(OH)维生素D越低,肝脏脂肪含 量越高,血清25(OH)维生素D有望成为NAFLD的预测指标。
Abstract:
Objective To investigate the relationship between serum 25(OH) vitamin D and liver fat content in nonalcoholic fatty liver disease (NAFLD). Methods A total of 120 patients with NAFLD admitted in our hospital between June and August, 2017 were enrolled and divided into 4 groups with different serum 25 (OH) vitamin D levels: >75 nmol/L (group A, n=25), 50-75 nmol/L (group B, n=35), 25-50 nmol/L (group C, n=32), and <25 nmol/L (group D, n=28). For all the patients, serum 25 (OH) vitamin D level was measured by ELISA, and liver fat content was determined using in-phase opposed-phase T1WI sequences. The measurement data were compared among the 4 groups to assess the association between serum 25(OH) vitamin D level and liver fat content. Results The liver fat content appeared to be higher in group B (28.66±6.45%) and group C (38.74±11.47%) than in group A (22.79 ± 6.10%), but the difference was not statistically significant (P>0.05); the liver fat content in group D (54.79 ± 5.28%) was significantly higher than that in the other 3 groups (P>0.05). Liver fat content increased significantly as serum 25(OH) vitamin D level decreased, showing an inverse correlation between them in these patients (P<0.05, r=-0.125). Conclusion In patients with NAFLD, a decreased serum 25(OH) vitamin D level is associated with an increased liver fat content, suggesting the value of serum 25(OH) vitamin D as a predictor of NAFLD.
更新日期/Last Update: 1900-01-01