[1]田建伟,谢婷婷,邱卓琳,等.精浆中晚期氧化蛋白产物水平与畸精子症及体外受精结局参数的关系[J].南方医科大学学报,2019,(08):937.[doi:10.12122/j.issn.1673-4254.2019.08.10]
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精浆中晚期氧化蛋白产物水平与畸精子症及体外受精结局参数的关系()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2019年08期
页码:
937
栏目:
出版日期:
2019-08-31

文章信息/Info

Title:
Association of advanced oxidation protein products in seminal plasma with teratospermia and outcome parameters of in vitro fertilization
作者:
田建伟谢婷婷邱卓琳刘婧张嘉琳叶文婷宋亚丽
关键词:
畸精子症晚期氧化蛋白产物体外受精
Keywords:
teratospermia advanced oxidation protein products in vitro fertilization
DOI:
10.12122/j.issn.1673-4254.2019.08.10
摘要:
目的研究精浆中晚期氧化蛋白产物(AOPPs)水平与畸精子症及体外受精(IVF)结局参数的关系。方法采用横断面调查 研究,收集我院生殖中心2018年10月~2019年3月接受辅助生殖治疗的272例男性精浆进行AOPPs和活性氧(ROS)水平检测, 并统计人口学指标、精液参数和体外受精结局指标。按照精子正常形态百分比,将助孕前患者分为畸精子症组与正常精子形态 组,再将畸精子症组分为轻、中、重度3个亚组。按照受精率中位数,将取卵日患者分为Ⅰ组(低于中位数组)与Ⅱ组(高于中位数 组)。结果助孕前精浆AOPPs(P=0.003)和ROS(P=0.013)水平与精子形态百分比呈显著负相关,畸精子症组精浆AOPPs(P= 0.027)和ROS(P=0.036)水平显著升高(P=0.027),其中重度畸精子症组AOPPs 水平显著高于轻度(P=0.019)和中度组(P= 0.015)。取卵日精浆AOPPs(P=0.003)和ROS(P=0.017)水平与体外受精受精率呈显著负相关,Ⅰ组精浆AOPPs(P=0.049)和 ROS(P=0.036)水平显著高于Ⅱ组。结论精浆中AOPPs水平的异常升高可能预示着男性发生重度畸精子症及体外受精受精率 低下的风险增高。
Abstract:
Objective To study the association of the level of advanced oxidation protein products (AOPPs) in seminal plasma with teratospermia and the outcome parameters of in vitro fertilization (IVF). Methods We conducted a cross-sectional study among 272 male patients receiving assisted reproduction treatment in the Center for Reproductive Medicine of our hospital between October, 2018 and March, 2019. The levels of seminal AOPPs and reactive oxygen species (ROS), demographic data, sperm parameters and IVF outcome parameters were analyzed for all the patients. According to the percentage of sperms with normal morphology, the patients were divided before IVF into teratozoospermia group and normal sperm morphology group, and those in teratozoospermia group were further divided into 3 subgroups with mild, moderate and severe teratozoospermia. The patients were also divided on the day oocyte retrieval into 2 groups with fertilizing rates lower (group I) and higher (group II) than the median rate. Results We found a significant negative correlation of seminal AOPP level before treatment with the percentage of normal sperm morphology (P=0.003) and seminal ROS level (P=0.013). The seminal levels of AOPPs (P= 0.027) and ROS (P=0.036) were significantly elevated in patients with teratospermia, and seminal AOPP level was significantly higher in severe teratospermia group than in mild (P=0.019) and moderate (P=0.015) teratospermia groups. The seminal levels of AOPPs (P=0.003) and ROS (P=0.017) on the day of oocyte retrieval were negatively correlated with the fertilization rate in IVF cycles, and the levels of AOPPs (P=0.049) and ROS (P=0.036) were significantly higher in group I than in group II. Conclusion An elevated level of seminal AOPPs may indicate an increased risk of severe teratospermia and a lower fertilization rate in IVF.

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更新日期/Last Update: 1900-01-01