[1]史琳娜,王柯,邓玉娣,等.脂噬对脂质代谢的调节作用及其分子机制[J].南方医科大学学报,2019,(07):867.[doi:10.12122/j.issn.1673-4254.2019.07.19]
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脂噬对脂质代谢的调节作用及其分子机制()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2019年07期
页码:
867
栏目:
出版日期:
2019-07-15

文章信息/Info

Title:
Role of lipophagy in the regulation of lipid metabolism and the molecular mechanism
作者:
史琳娜王柯邓玉娣王莹娜朱双玲杨旭珊廖文镇
关键词:
自噬脂质代谢分子机制
Keywords:
autophagy lipid metabolism molecular mechanism
DOI:
10.12122/j.issn.1673-4254.2019.07.19
摘要:
最新研究发现了一种选择性自噬——脂噬,其可以选择性识别脂质并将其降解,在调节细胞脂肪代谢、维持细胞内脂质稳 态等过程中发挥着重要的作用。脂噬过程会受到基因、酶、转录调节因子等多种因素的直接或间接调节作用。在本文中,我们 重点综述了脂噬降低肝脏脂肪含量、调节胰腺脂质代谢异常以及调控脂肪组织分化的功能,并对目前发现参与调节脂噬作用的 分子(Rab GTPase、酶、离子通道、转录因子、小分子物质)进行了归纳,旨在为治疗由脂肪堆积引发的各种疾病指引新的方向。
Abstract:
Recent studies have discovered a selective autophagy—lipophagy, which can selectively identify and degrade lipids and plays an important role in regulating cellular lipid metabolism and maintaining intracellular lipid homeostasis. The process of lipophagy can be directly or indirectly regulated by genes, enzymes, transcriptional regulators and other factors. This review examines the role of lipophagy in reducing liver lipid content, regulating pancreatic lipid metabolism, and regulating adipose tissue differentiation, and summarizes the findings of the molecules (Rab GTPase, enzymes, ion channels, transcription factors, small molecular substances) involved in the regulation of lipophagy, which points to new directions for the treatment of diseases caused by lipid accumulation.

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更新日期/Last Update: 1900-01-01