[1]董海平,刘志辉,梁小成,等.血浆干扰素诱导蛋白10 在不同受累范围肺结核患者血浆中的表达[J].南方医科大学学报,2019,(05):609.[doi:10.12122/j.issn.1673-4254.2019.05.18]
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血浆干扰素诱导蛋白10 在不同受累范围肺结核患者血浆中的表达()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2019年05期
页码:
609
栏目:
出版日期:
2019-05-15

文章信息/Info

Title:
Plasma levels of interferon-inducible protein 10 in patients with active pulmonary tuberculosis with different affected areas
作者:
董海平刘志辉梁小成简奕娈李德宪劳穗华梁锋潘燕珊邝小佳
关键词:
干扰素γ诱导蛋白10肺结核辅助诊断疾病严重程度
Keywords:
interferon-inducible protein 10 pulmonary tuberculosis auxiliary diagnosis severity of the disease
DOI:
10.12122/j.issn.1673-4254.2019.05.18
摘要:
目的探讨干扰素诱导蛋白10(IP-10)在活动性肺结核辅助诊断及判断病情严重程度方面的参考价值。方法选择本院 2013年2月~2017年2月健康体检者84例为对照组及住院肺结核患者193例为结核组,应用液相芯片Luminex技术检测观察对 象血浆中IFN-γ和IP-10细胞因子的表达量。将结核组根据病灶范围所占面积可继续分为A组(1~2个肺野)、B组(3~4个肺野) 和C组(5~6个肺野),比较3组患者IFN-γ和IP-10的表达差异。结果结核组患者血浆中IP-10的表达高于对照组,差异有统计 学意义(P<0.05),而两组间IFN-γ的差异无统计学意义(P>0.05);IP-10在C组明显随病灶增多而升高,与其他组的差异有统计 学意义(P<0.05),而IFN-γ在各组之间差异无统计学意义(P>0.05)。结论血浆IP-10对活动性肺结核的辅助诊断及病情严重程 度的判断方面是具有一定的参考价值。
Abstract:
Objective To explore the value of interferon-inducible protein 10 (IP-10) in the auxiliary diagnosis of tuberculosis and the judgment of the severity of disease. Methods From February, 2013 to February, 2017, a total of 193 patients with TB admitted in our hospital and 84 healthy control subjects were recruited consecutively. The peripheral blood plasma levels of interferon-γ (IFN-γ) and IP-10 were detected using liquid phase chip (Luminex) technique. According to the number of lung fields affected by TB, the patients were divided into group A (with lesions in 1-2 lung fields), group B (3-4 lung fields) and group C (5-6 lung fields), The expressions of IFN-γ and IP-10 in 3 groups were compared. Results The plasma levels of IP-10 were significantly higher in TB patients than in the control subjects (P<0.05), but IFN-γ levels were comparable between the two groups (P>0.05). Among the TB patients, plasma IP-10 levels was the highest in group C (P<0.05), and IFN-γ levels did not differ significantly among the 3 groups (P>0.05). Conclusion Plasma IP-10 has a certain reference value in the auxiliary diagnosis of active tuberculosis and the judgment of the severity of the disease.

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更新日期/Last Update: 1900-01-01