[1]刘华熙,吕智豪,田春阳,等.肾病Ⅲ号方治疗慢性肾脏病蛋白尿的机制:基于网络药理学方法[J].南方医科大学学报,2019,(02):227.[doi:10.12122/j.issn.1673-4254.2019.02.16]
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肾病Ⅲ号方治疗慢性肾脏病蛋白尿的机制:基于网络药理学方法()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2019年02期
页码:
227
栏目:
出版日期:
2019-02-28

文章信息/Info

Title:
Mechanism of Shenbing decoction III in the treatment of proteinuria in chronic kidney disease: a network pharmacology-based study
作者:
刘华熙吕智豪田春阳欧阳文坤熊一凡游艳婷陈立倩邓伊健赵晓山孙晓敏
关键词:
网络药理学肾病Ⅲ号方慢性肾脏病蛋白尿作用机制
Keywords:
network pharmacology Shenbing decoction III chronic kidney disease proteinuria mechanism
DOI:
10.12122/j.issn.1673-4254.2019.02.16
摘要:
目的基于网络药理学探讨肾病Ⅲ号方的主要活性成分、靶点及治疗慢性肾脏病蛋白尿的作用机制。方法结合口服生物 利用度和类药性,在TCMSP数据库中寻找与肾病Ⅲ号方组方中药相关的活性成分、靶点,在GeneCards数据库搜索蛋白尿相关 靶点,采用Cytoscape软件构建活性成分-靶点网络,并将获取的靶点信息利用ClueGO进行基因通路的富集分析。结果从肾病 Ⅲ号方中筛选获得102个活性成分、作用于126个靶点,与蛋白尿相关的靶点69个,流体剪切应力和动脉粥样硬化相关通路显 著性高。结论初步验证了肾病Ⅲ号方的组方合理性及其治疗慢性肾脏病蛋白尿的科学性,并为进一步深入探讨肾病Ⅲ号方治 疗慢性肾脏病蛋白尿的机制奠定理论基础。
Abstract:
Objective To identify the main active components in Shenbing decoction III and their targets and explore the mechanism by which Shenbing decoction III alleviates proteinuria in chronic kidney disease (CKD) based on network pharmacology. Methods The active components of Shenbing decoction III and their potential targets, along with the oral bioavailability and drug-like properties of each component were searched in the TCMSP database. The proteinuria-related targets were searched in the GeneCards database. The active component-target network was constructed using Cytoscape software, and the acquired information of the targets from ClueGO was used for enrichment analysis of the gene pathways. Results A total of 102 active components were identified from Shenbing decoction III. These active components acted on 126 targets, among which 69 were related to proteinuria. Enrichment analysis revealed fluid shear stress- and atherosclerosisrelated pathways as the highly significant pathways in proteinuria associated with CKD. Conclusion We preliminarily validated the prescription of Shenbing decoction III and obtained scientific evidence that supported its use for treatment of proteinuria in CKD. The findings in this study provide a theoretical basis for further study of the mechanism of Shenbing decoction III in the treatment of proteinuria in CKD.
更新日期/Last Update: 1900-01-01