[1]曹赛,程梅容,刘素娥,等.食管癌组织中TAK1 和TAB1 的表达及与临床预后的相关性[J].南方医科大学学报,2018,(07):895.
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食管癌组织中TAK1 和TAB1 的表达及与临床预后的相关性()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2018年07期
页码:
895
栏目:
出版日期:
2018-06-30

文章信息/Info

Title:
Expressions of TAK1 and TAB1 in esophageal cancer and their correlation with prognosis
作者:
曹赛程梅容刘素娥段晓乐李梅
关键词:
食管癌TAK1TAB1复发预后
Keywords:
esophageal cancer TAK1 TAB1 recurrence prognosis
摘要:
目的探讨食管癌组织中转化生长因子激活激酶1(TAK1)和转化生长因子β活化激酶结合蛋白1(TAB1)在食管癌组织中 的表达相关性,并分析其与临床病理特征及预后的关系。方法采用免疫组织化学染色法检测TAK1和TAB1蛋白在84例食管 癌组织、配对的癌旁组织中的表达;根据TAK1高/低表达、TAB1高/低表达、TAK1及TAB1共表达与否等将其分为三种表达方 式,并分析其表达方式与临床病理特征的相关性;采用生物信息学数据库分析TAK1 和TAB1 基因表达之间的相关性;采用 Kaplan-Meier 方法进行无瘤时间生存分析。结果TAK1 和TAB1 在食管癌组织中的高表达率分别为65.5%(55/84)和52.4% (44/84),且两者的表达及共表达均与食管癌浸润深度、淋巴结转移、病理TNM分期相关(P<0.05)。TAK1与TAB1的表达量呈 正相关性(P<0.05),高表达TAK1或共表达TAK1/TAB1提示患者无瘤生存期缩短。结论TAK1和TAB1影响食管癌的疾病进 展及预后,联合检测两者表达可能作为食管癌新的预后指标和治疗靶点。
Abstract:
Objective To detect the expressions of transforming growth factor-β (TGF-β)-activated kinase (TAK1) and TGF-β- activated protein kinase 1 (TAB1) in esophageal cancer tissues and explore their correlations with the clinicopathological features and prognosis of the patients. Methods The expressions of TAK1 and TAB1 in 84 esophageal cancer tissues and paired adjacent tissues was detected using immunohistochemical staining. The correlations of different patterns of TAK1 and TAB1 expressions (TAK1 alone, TAB1 alone, and both) with the clinicopathological features of the patients were analyzed. The correlation between TAK1 and TAB1 was assessed based on GEPIA datasets. Kaplan- Meier survival analysis was used to analyze the recurrence-free survival of the patients in relation with TAK1 and TAB1 expressions. Results TAK1 and TAB1 were highly expressed in 65.5% (55/84) and 52.4% (44/84) of the esophageal cancer tissues, respectively. The expression of TAK1, TAB1 and their co-expression were all correlated with tumor invasion depth, lymph node metastasis, and TNM staging (P< 0.05). A strong correlation was found between TAK1 and TAB1 expressions. A high expression of TAK1 and TAK1/TAB1 co-expression both predicted a poor recurrence-freed survival of the patients (P<0.05). Conclusion TAK1 and TAB1 are associated with the progression and prognosis of esophageal cancer and can serve as new prognostic biomarkers for esophageal cancer and as potential molecular targets for therapies.

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更新日期/Last Update: 1900-01-01