[1]焦根龙,范永保,邓德均,等.显微镜下脊髓髓内外减压、灌洗疗法在慢性颈髓损伤中的疗效及机制[J].南方医科大学学报,2018,(02):174.
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显微镜下脊髓髓内外减压、灌洗疗法在慢性颈髓损伤中的疗效及机制()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2018年02期
页码:
174
栏目:
出版日期:
2018-02-15

文章信息/Info

Title:
Efficacy of intramedullary and extramedullary decompression and lavage therapy under microscope for treatment of chronic cervical spinal cord injury
作者:
焦根龙范永保邓德均邵建立孙国栋李志忠
关键词:
显微镜脊髓损伤炎症因子髓内减压
Keywords:
microscope spinal cord injury inflammatory factors intramedullary decompression
摘要:
目的探讨脊髓髓内外减压、灌洗疗法对慢性颈髓损伤临床疗效分析及可能机制。方法随访我院自2008年1月~2015 年1月慢性颈髓损伤患者57 例,致病原因多节段颈椎间盘突出17 例,长节段OPLL 25 例,颈椎黄韧带肥厚或钙化13 例,陈旧 性颈椎骨折2例。单纯髓外减压31例设为A组,采用后路单开门、椎管减压、椎管成形术式;髓内外减压26例设为B组,采用后 路单开门、脊膜切开减压、松解黏连、大量生理盐水灌洗、椎管成形术式,该组打开硬脊膜、松解后在损伤部位取脑脊液送检检测 炎症因子水平。随访期间定期进行JOA 评分,定期记录术前、术后JOA评分并计算改善率,同时复查X 线、CT 或MRI。结果 术后2周影像学提示原发病变两组均较好解除,B组脊髓高信号改善情况较A组好;A、B两组术后1年内各时期JOA评分均高 于术前(P<0.05),两组间比较术后1年内各时期B组的JOA评分及改善率均高于A 组,两组间比较有统计学差异(P<0.05),其 中术前两组JOA评分无统计学差异(P>0.05)说明术后1年内B 组均较A 组获得更好近期疗效。A组3例出现脑脊液漏(均为 OPLL患者),1例出现硬膜外血肿,1例出现内固定松动;B组有1例出现门轴断裂。B 组较A组术后恢复时间短,3个月进入平 台期。脑脊液检测结果显示脊髓损伤部位促炎因子IFN-γ、IL-17F、IL-6、sCD40L含量较正常脑脊液明显增高,其中IL-6因子增 高最为显著,各组增高促炎因子与正常值比较均有统计学意义(P<0.05)。结论慢性颈髓损伤在显微镜下采用髓内外减压较单 纯髓外减压能获得较好疗效,这可能与显微镜下切开硬脊膜、松解黏连、解除慢性压迫及降低损伤部位炎症因子水平相关。改 变局部微环境可促进神经功能恢复,缩短进入平台期的时间,从而改善愈后的功能、获得更好的临床疗效。
Abstract:
Objective To analyze the clinical effect of spinal cord decompression and lavage therapy on chronic cervical spinal cord injury and explore the possible mechanism. Methods Fifty-seven patients with chronic cervical spinal cord injury treated in our hospital from January, 2008 to January, 2015 were enrolled, including 17 with multilevel cervical disc herniation, 25 with long segmental ossification of the posterior longitudinal ligament, 13 with hypertrophy or calcification of neck ligamentum flavum, and 2 with old cervical fractures. Open-door spinal canal laminoplasty via a posterior approach and decompression in simple extramedullary decompression was performed in 31 cases (group A), and open-door spinal cord incision decompression via a posterior approach, saline irrigation, and spinal canal laminoplasty in intramedullary decompression was performed in 26 cases (group B). The pre-operative cerebrospinal fluid in group B patients was collected to examine the inflammatory factors. All the patients were followed up and evaluated for pre- and postoperative JOA scores to calculate the improvement rate with regular examinations by X-ray, CT or MRI. Results Imaging examinations 2 weeks after the operation showed obvious relief of the primary lesion in both groups, and the improvement of high signals was better in group B than in group A. The mean improvement rate at 12 months after the operation was 52.33% in group A and 61.52% in group B (P<0.05), and the mean JOA score was significantly higher in group B than in group A (14.80±1.51 vs 13.58±0.56; P<0.05). Cerebrospinal fluid leakage occurred in 3 cases, epidural hematoma in 2 cases, internal fixation loosening in 1 case in group A; portal shaft fracture and internal fixation loosening occurred in 1 case in group B. Postoperative recovery time was shorter in group B and entered the platform phase in 3 months. The inflammatory factors IFN-γ, IL-17F, IL-6 and sCD40L were all significantly higher than the normal levels after spinal cord injury, and the increment of IL-6 was the most conspicuous (P<0.05). Conclusion Intramedullary and extramedullary decompression can achieve better outcomes than extramedullary decompression in patients with chronic cervical cord injury. This may be related not only to relieving adhesions and secondary compression by cutting the dura under the microscope, but also to removal of local inflammatory factors.

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更新日期/Last Update: 1900-01-01