[1]陈建新,江冠铭,李瑞平,等.空肠多发肉瘤样癌术后肺、脑转移:1例报告并文献复习[J].南方医科大学学报,2017,(12):1695.
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空肠多发肉瘤样癌术后肺、脑转移:1例报告并文献复习()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2017年12期
页码:
1695
栏目:
出版日期:
2017-12-20

文章信息/Info

Title:
Multiple primary sarcomatoid carcinoma of the jejunum with postoperative lung and brain metastases: a case report and literature review
作者:
陈建新江冠铭李瑞平李力波王静仪
关键词:
肉瘤样癌空肠肺、脑转移文献复习
Keywords:
primary sarcomatoid carcinoma jejunum lung and brain metastases literature review
摘要:
目的探讨空肠肉瘤样癌患者的临床表现、治疗及预后等特点,为临床诊治提供参考。方法本文报道1例我院收治的空肠 多发肉瘤样癌术后肺、脑转移患者,并分析14篇个案报道、共18例病例。结果患者因肠套叠并消化道出血,行空肠部分切除 术,术后4月出现脑、肺等多发转移,术后8月因多器官功能衰竭而死亡。空肠肉瘤样癌国内外命名不统一,诊断困难,尤其难以 早期明确诊断,主要诊断依据为病理检查和免疫组化。目前无明确的治疗指南,包括肿瘤在内的广泛手术切除是主要有效治疗 手段,但预后极差,中位生存期仅为5.5月(0.36~36月),多死于复发和转移。结论空肠肉瘤样癌较罕见,本例空肠多发性发病 并发脑等部位转移更加罕见。规范命名、尽早诊断、通过全身多部位扫描明确其他部位是否存在癌灶、充分评估病程以及尽早 治疗均十分重要。手术是治疗的基础,可尝试运用各种肿瘤局部治疗手段。Ki-67作为预后判断和PD-L1靶向免疫治疗的潜在 价值需进一步探究。
Abstract:
Objective We report a rare case of a multiple sarcomatoid carcinoma of the jejunum with postoperative lung and brain metastases. The patient underwent jejunum segmental resection for intussusception and gastrointestinal bleeding. Multiple metastasis ofbrain and lung occurred 4 months after the operation, and the patient died for multiple organ failure 8 months after the surgery. Primary sarcomatoid carcinoma was difficult to diagnose at an early stage, and the diagnosis relies on optical microscopic and immunohistochemical observations. Currently no guidelinesare established for treatment for sarcomatoid carcinoma of the jejunum, and surgical resection remains the optimal therapeutic approach. Previous reports documented a poor prognosis of the patients with a median survival time of 5.5 months (0.36- 36months), and the primary causes of death were tumor recurrence and metastasis. Ki-67 as a potential prognostic marker and the value of PD-L1-targeted immunotherapy for the treatment await further investigation.

相似文献/References:

[1]陈群清,陈燕春,闫玉生,等.带血管蒂空肠在重建消化道中的应用[J].南方医科大学学报,2004,(02):238.
 CHEN Qun-qing,CHEN Yan-chun,YAN Yu-sheng,et al.Application of jejunum with vascular pedicle in reconstruction of the digestive tract[J].,2004,(12):238.

更新日期/Last Update: 1900-01-01