[1]武世伍,王一超,慈红非,等.血管生成抑制蛋白1和结肠癌转移相关蛋白-1在肺鳞状细胞癌中的表达及其临床意义[J].南方医科大学学报,2017,(07):952.
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血管生成抑制蛋白1和结肠癌转移相关蛋白-1在肺鳞状细胞癌中的表达及其临床意义()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2017年07期
页码:
952
栏目:
出版日期:
2017-07-20

文章信息/Info

Title:
Expression of vasohibin-1 and MACC1 in lung squamous cell carcinoma and their clinicopathological significance
作者:
武世伍王一超慈红非陶仪声
关键词:
肺鳞状细胞癌vasohibin-1MACC1免疫组织化学预后
Keywords:
lung squamous cell carcinoma vasohibin-1 MACC1 immunohistochemistry prognosis
摘要:
目的检测肺鳞状细胞癌(LSCC)中血管生成抑制蛋白1(vasohibin-1)和结肠癌转移相关蛋白-1(MACC1)蛋白的表达及 其相互之间的关系,并探讨它们与LSCC患者临床病理因素的关系。方法利用免疫组织化学ElivisionTM plus方法检测160例 LSCC和80例正常肺组织中vasohibin-1和MACC1蛋白的表达情况。结果在LSCC组织中,vasohibin-1和MACC1蛋白的表 达阳性率分别为59.4%和57.5%;对照组中,vasohibin-1和MACC1蛋白的表达阳性率分别为11.3%和8.8%,其表达差异在两组 之间有统计学意义(P<0.05)。vasohibin-1和MACC1蛋白的表达阳性率在LSCC患者肿瘤组织的不同分化程度之间、淋巴结转移 与否之间以及TNM不同分期之间差异均有统计学意义(P<0.05);且vasohibin-1蛋白的表达阳性率与MACC1蛋白的表达阳性 率之间呈正相关关系(P<0.001)。Kaplan-Meier生存分析表明在LSCC中vasohibin-1和MACC1蛋白阳性表达组患者术后总的 生存时间明显低于其阴性组患者,log-rank分析其差异均有统计学意义。多因素回归分析表明vasohibin-1和MACC1蛋白的阳性 表达及TNM分期是影响LSCC患者术后生存的独立预后因子。结论异常表达的vasohibin-1和MACC1可能参与了LSCC的发 展,并促进其浸润和转移;在LSCC患者中联合检测vasohibin-1和MACC1蛋白的表达对预测其发展和预后均有重要意义。
Abstract:
Objective To investigate the expressions of vasohibin-1 and MACC1 in lung squamous cell carcinoma (LSCC) and their associations with the clinicopathological characteristics of the patients. Methods The expressions of vasohibin-1 and MACC1 proteins were examined with immunohistochemistry in 160 LSCC tissues and 80 normal lung tissues. Results The positivity rates of vasohibin-1 and MACC1 proteins were 59.4% and 11.3% in LSCC tissues, respectively, which were significantly higher than the rates in normal lung tissues (57.5% and 8.8%, respectively; P<0.05). The expressions of vasohibin-1 and MACC1 proteins were significantly correlated with the tumor grades, lymph node metastasis, and TNM stages (all P< 0.05). Spearman correlation analysis indicated a positive correlation between vasohibin-1 expression and MACC1 expressions (P<0.001). Kaplan-Meier survival analysis showed that LSCC patients with a positive expression of vasohibin-1 had significantly shorter overall survival time than those negative for vasohibin-1; the overall survival time was also significantly shorter in patients positive for MACC1 than in those negative for MACC1 (both P<0.05). Multivariate COX regression analysis indicated that positive expressions of vasohibin-1 and MACC1 protein and TNM stage were independent prognostic factors of LSCC. Conclusion Aberrant expressions of vasohibin-1 and MACC1 may participate in the development and promote invasion and metastasis of LSCC. The combined detection of vasohibin-1 and MACC1 expression may provide important evidence for predicting the progression and prognosis of LSCC.

相似文献/References:

[1]彭淑贤,李浔,刘琴,等.转录组数据分析肺腺癌和肺鳞状细胞癌中基因的差异表达[J].南方医科大学学报,2019,(06):641.[doi:10.12122/j.issn.1673-4254.2019.06.03]

更新日期/Last Update: 1900-01-01