[1]钟素兰,倪佳,柴巧学,等.牙周非手术治疗对肥胖大鼠血清炎症指标及代谢水平的影响[J].南方医科大学学报,2017,(06):807.
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牙周非手术治疗对肥胖大鼠血清炎症指标及代谢水平的影响()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2017年06期
页码:
807
栏目:
出版日期:
2017-06-20

文章信息/Info

Title:
Effects of non-surgical periodontal therapy on serum inflammatory markers and metabolic level in obese rats
作者:
钟素兰倪佳柴巧学陈蕾章锦才
关键词:
牙周非手术治疗肥胖炎症因子代谢水平
Keywords:
non-surgical periodontal therapy obesity inflammatory markers metabolism
摘要:
目的探讨牙周非手术治疗对肥胖大鼠血清炎症因子及代谢水平的影响。方法选取16只已成功建立肥胖复合牙周炎模 型的大鼠,随机分为治疗组及未治疗组(对照组),治疗组大鼠接受牙周非手术治疗,对照组未做任何处理,所有大鼠于牙周治疗 后2周处死。牙周治疗前及治疗后2周两组大鼠均行口服糖耐量试验,眼眶静脉取血、检测空腹血糖及空腹胰岛素,运用酶联免 疫吸附法检测血清C-反应蛋白(CRP)。结果牙周治疗后2周,治疗组的空腹血糖(t=2.445, P=0.034)及β细胞功能指数显著低 于对照组(t=-2.543, P=0.027);经牙周治疗后,治疗组CRP水平显著降低,并低于对照组(t=2.388, P=0.028);口服糖耐量试验 中,曲线下面积显著下降,并低于对照组(t=12.053, P=0.000)。结论牙周非手术治疗可以下调肥胖复合牙周炎大鼠的CRP水 平,改善肥胖大鼠的糖代谢状况。
Abstract:
Objective To investigate the effects of non-surgical periodontal therapy on serum inflammatory factors and metabolism levels in obese rats with experimental periodontitis. Methods Sixteen obese rats with experimental periodontitis were randomly divided into treatment group and control group with non-surgical periodontal therapy and no treatment, respectively. Oral glucose tolerance test was performed before treatment and 2 weeks after the treatment. All the rats were sacrificed 2 weeks after treatment and the orbital vein blood was taken to detect fasting blood glucose, fasting insulin, and serum level of C-reactive protein (CRP). Results Two weeks after periodontal treatment, fasting blood glucose (t=2.445, P= 0.034) and beta cell function index (t=-2.543, P=0.027) were significantly lower in the treatment group than in the control group. Compared with those in the control group, CRP level (t=2.388, P=0.028) and the area under the curve in the oral glucose tolerance test (t=12.053, P=0.000) decreased significantly in the treatment group. Conclusion Non-surgical periodontal treatment can reduce serum CRP level and improve glucose metabolism in obese rats.

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更新日期/Last Update: 1900-01-01