[1]张书新,刘阳.肾移植术后并发原发性肺癌的单中心研究[J].南方医科大学学报,2017,(06):715.
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肾移植术后并发原发性肺癌的单中心研究()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2017年06期
页码:
715
栏目:
出版日期:
2017-06-20

文章信息/Info

Title:
Primary lung cancer in Chinese renal transplant recipients: a single-center analysis
作者:
张书新刘阳
关键词:
肺癌肾移植外科手术免疫抑制预后
Keywords:
lung cancer renal transplantation surgery immunosuppression prognosis
摘要:
:目的回顾性分析肾移植术后原发性肺癌的临床特点及预后。方法自1988年1月~2015年4月期间,2793例患者在我院 接受肾移植手术。14例(0.5%)患者随后发展为肺癌,其中10例(71.4%)接受了手术治疗。结果肾移植时患者的平均年龄为 50.2±8.3岁。14例肺癌患者中,10例(71.4%)有吸烟史。9例(64.3%)为偶然发现,而有症状者仅为5例。从移植手术到肺癌诊 断的平均时间间隔为65.7±20.1个月。统计结果显示,不同肿瘤分期病人的生存率具有统计学差异(P=0.001)。随访期间有11 例死于肿瘤转移或器官衰竭,3例存活。肺癌诊断后的总体5年生存率为17.9%。结论肾移植术后原发性肺癌的危险性可能高 于一般人群。肾移植术后常规胸部检查可早期发现原发性肺癌,对于及早施行手术、改善预后很有必要。
Abstract:
Objective To evaluate the clinical characteristics and the outcomes of primary lung cancer in renal recipients. Methods Between January, 1988 and April, 2015, a total of 2793 consecutive patients underwent renal transplantation at our center. Fourteen (0.5%) patients subsequently developed lung cancer, for which 10 (71.4%) received surgical treatment. Results The mean age of the 14 patients with post-transplant lung cancer was 50.2±8.3 years at transplantation, and 10 of them (71.4%) were former smokers. In 9 (64.3% ) of 14 patients, the malignancies were detected incidentally and 5 patients were symptomatic. The average interval from transplantation to cancer diagnosis was 65.7±20.1 months. Eleven patients died from cancer metastasis or organ failure and 3 remained alive with functioning graft. The survival rates of the patients with lung cancer in different stages were statistically different (P=0.001). The overall 5-year survival rate after diagnosis was 17.9% in these 14 patients. Conclusion The risk of primary lung cancer might be higher in renal transplant recipients than in the general Chinese population. Routine chest screening for lung cancer in renal transplant recipients may help in early detection and treatment of the malignancy to improve the prognosis.

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更新日期/Last Update: 1900-01-01