[1]李辉,李妙男,康品方,等.细胞色素P450 3A4+894C>T基因多态性与急性冠脉综合症患者冠状动脉介入术预后的关系[J].南方医科大学学报,2017,(02):261.
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细胞色素P450 3A4+894C>T基因多态性与急性冠脉综合症患者冠状动脉介入术预后的关系()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2017年02期
页码:
261
栏目:
出版日期:
2017-01-22

文章信息/Info

Title:
Correlation between cytochrome 3A4+894C>T P450 gene polymorphism and outcomes of coronary intervention in patients with acute coronary syndrome
作者:
李辉李妙男康品方李扬汤阳卢冬雨史晓俊王洪巨
关键词:
CYP3A4 基因多态性急性冠脉综合征氯吡格雷抵抗经皮冠状动脉介入术
Keywords:
CYP3A4 gene polymorphism acute coronary syndrome clopidogrel resistance percutaneous coronary intervention
摘要:
目的探讨急性冠脉综合征(ACS)患者血浆细胞色素P450 3A4(CYP3A4)894C>T基因多态性与接受经皮冠状动脉介入 (PCI)治疗后患者心脏不良事件再发风险的关系。方法入选275例接受标准双联抗血小板及PCI术治疗的ACS患者。在服用 抗血小板药物前及7 d 后检测每位患者的血小板聚集率(PAR)。采用基因芯片及PCR技术检测每组内患者CYP3A4 基因 894C>T单核苷酸多态性的基因型和等位基因分布。通过PCI术明确患者的冠脉病变数目并计算其Gensini评分。出院后随访 3~12月。结果CYP3A4 基因多态性在氯吡格雷抵抗(CR)组和非氯吡格雷抵抗(NCR)组的差异无统计学意义(P>0.05)。多因 素Logistic回归分析显示,CYP3A4 基因894C>T位点中携带T突变基因与ACS患者发生CR的相关性差异无统计学意义(OR 1.359, P>0.05)。随访3~12月后,CR组较NCR组均有更高的心血管事件发生率(P<0.05),但与CYP3A4 基因894C>T位点的 突变类型无关。结论CYP3A4 基因894C>T位点的多态性对ACS患者PCI术后抗血小板效应及心血管发生风险无明确指导 意义。
Abstract:
Objective To investigate the relationship between plasma cytochrome P450 3A4 (CYP3A4) 894C>T gene polymorphism and the risk of recurrence of adverse cardiac events after percutaneous coronary intervention (PCI) in patients with acute coronary syndrome (ACS). Methods A total of 275 patients with ACS received standard dual antiplatelet therapy and PCI. Platelet aggregation rate (PAR) was detected in each patient before and 7 days after administration of the anti-platelet drugs. Single nucleotide polymorphism of CYP3A4 gene 894C>T was detected with PCR and microarray technique. The number of coronary artery lesions was determined by PCI and the Gensini score was calculated. The patients were followed up for 3-12 months after discharge. Results No significant difference was found in CYP3A4 gene polymorphism between patients with clopidogrel resistance (CR group) and those without CR (NCR group) (P>0.05). Multivariate logistic regression analysis showed that CYP3A4 gene 894C>T polymorphism was not correlated with CR in patients with ACS (OR 1.359, P>0.05). During the follow-up, the incidence of cardiovascular events was significantly higher in CR group than in NCR group (P<0.05), but this difference was not related to the mutation type of 894C>T locus of CYP3A4 gene. Conclusion The CYP3A4 gene 894C>T polymorphism is not associated with the effect of anti-platelet therapy and the risk of cardiovascular event in patients with ACS following PCI.

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更新日期/Last Update: 1900-01-01