[1]欧阳辉,何雪常,周毅,等.系统性红斑狼疮合并带状疱疹病毒感染的免疫抑制[J].南方医科大学学报,2016,(11):1577.
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系统性红斑狼疮合并带状疱疹病毒感染的免疫抑制()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2016年11期
页码:
1577
栏目:
出版日期:
2016-11-20

文章信息/Info

Title:
Analysis of immune suppression in patients with systemic lupus erythematosus complicated by herpes zoster virus infection
作者:
欧阳辉何雪常周毅李朝霞
关键词:
系统性红斑狼疮带状疱疹免疫物理治疗
Keywords:
systemic lupus erythematosus herpes zoster immunity physical therapy
摘要:
目的探讨系统性红斑狼疮(SLE)合并带状疱疹(HZ)病毒感染的临床免疫特点及物理治疗安全性。方法回顾性分析10 例合并HZ感染的SLE患者,与同期住院的无感染的SLE患者30例比较,观察两组的一般资料,发病前、发病时、治愈后的实验 室指标及T淋巴细胞亚群计数。结果两组患者一般资料无差异;常规实验室检查指标比较:SLE合并HZ组发病前中性粒细胞 绝对值升高、白细胞计数升高,发病时淋巴细胞百分比下降、C反应蛋白升高的比例差异有统计学意义(P<0.05);T淋巴细胞亚 群检查指标比较:SLE合并HZ组发病前CD3+百分率升高、CD16+CD56+百分率下降、4/8Ratio计数异常的比例差异有统计学意 义(P<0.01),CD8+百分率升高、CD8+计数升高、CD16+CD56+计数下降的比例差异有统计学意义(P<0.05);发病时CD3+百分率升 高、CD8+百分率升高、CD4+百分率下降、4/8Ratio计数异常的比例差异有统计学意义(P<0.05),CD16+CD56+百分率下降、CD8+ 计数升高的比例差异有统计学意义(P<0.01);治愈后CD16+CD56+百分率下降的比例差异有统计学意义(P<0.01)。HZ感染的 治疗时间5±1.3 d,治愈率100%,无后遗神经痛发生。结论SLE合并HZ感染存在免疫抑制状态。提示我们在SLE治疗过程中 应加强T淋巴细胞亚群的监测。抗病毒药物和物理治疗对SLE合并HZ感染的治疗安全、有效。
Abstract:
Objective To explore the changes in cellular immune function and the safety of physical therapy in patients with systemic lupus erythematosus (SLE) complicated by herpes zoster (HZ) virus infection. Methods A retrospective analysis was conducted among 10 SLE pateints with HZ virus infection, with 30 SLE patients without HZ infection as the control group. The results of routine laboratory tests and T lymphocyte subset counts (before and during infection and after cure of infection) were compared between the two groups. Results The proportion of patients with significantly increased absolute neutrophil count and white blood cell count before HZ infection, and those with decreased lymphocyte percentage and elevated C-reactive protein during infection differed significantly between the two groups (P<0.05). Before HZ infection, the proportions of patients with increased CD3+%, decreased CD16+CD56+%, abnormal 4/8 ratio (P<0.01) and those with increased CD8+% and CD8+ count and decreased CD16+CD56+ count differed significantly between the two groups (P<0.05). During HZ infection, the proportion of patients with increased CD3+% and CD8+% and decreased CD4+% and 4/8 ratio count (P<0.05) and those with decreased CD16+CD56+% and increased CD8+ count differed significantly between the two groups (P<0.01). After cure of HZ infection, the proportion of patients with decreased CD16 +CD56 +% was significantly different between the two groups (P<0.01). The treatment time of HZ infection averaged 5 ± 1.3 days with a cure rate of 100%; postherpetic neuralgia occurred in none of the patients after the treatment. Conclusion Patients with SLE complicated by HZ infection are in an immunosuppressive state, suggesting the need of monitoring T lymphocyte subsets in SLE treatment. The combined use of antiviral drugs and physical therapy can be safe and effective for treatment of SLE complicated by HZ infection.

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更新日期/Last Update: 1900-01-01