[1]谢芳,吕冬,陈伟斌,等.同型半胱氨酸与糖尿病微血管病变的相关性及药物干预后的变化[J].南方医科大学学报,2016,(11):1573.
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同型半胱氨酸与糖尿病微血管病变的相关性及药物干预后的变化()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2016年11期
页码:
1573
栏目:
出版日期:
2016-11-20

文章信息/Info

Title:
Correlation of homocysteine with diabetic microangiopathy and the change after drug intervention
作者:
谢芳吕冬陈伟斌林艳足
关键词:
糖尿病微血管病变同型半胱氨酸临床相关性
Keywords:
diabetes microvascular lesions homocysteine clinical correlation
摘要:
目的探讨同型半胱氨酸与糖尿病微血管病变的相关性及药物干预后的变化。方法2型糖尿病患者200例,根据患者微 血管并发症情况分为无微血管病变组和合并微血管病变组,所有患者治疗前及治疗6个月后进行血脂、血糖、肾功能及血清同 型半胱氨酸测定。另外按年龄和性别匹配的原则选择同期进行体检的健康受试者100例作为正常对照组。结果(1)无血管病 变组和合并微血管病变组患者常规测量收缩压(SBP)、舒张压(DBP)、甘油三酯(TG)、血脂测定包括总胆固醇(TC)、低密度脂 蛋白(LDL)、血糖测定包括空腹血糖(FBG)、餐后2 h 血糖(2 h PBG)、糖化血红蛋白(HbA1)、肾功能测定包括血清尿素氮 (SUN)、血清肌酐(Scr)和血浆同型半胱氨酸(HCY)水平均显著高于正常对照组(P<0.01),HDL水平显著低于正常对照组(P< 0.01);(2)合并微血管病变组患者的SBP、DBP、SUN、SCr和HCY水平显著高于无血管病变组(P<0.01);(3)多因素logistic回归 分析显示舒张压、尿素氮、血清肌酐和同型半胱氨酸水平是糖尿病患者发生微血管并发症的危险因素;(4)治疗后无微血管病变 组和合并微血管病变组组患者HCY水平均较治疗前显著降低(P<0.01)。结论高同型半胱氨酸水平是糖尿病微血管病变的高 危因素,经治疗后可降低患者同型半胱氨酸水平。
Abstract:
Objective To explore the correlation of homocysteine with diabetic microangiopathy and the change after drug intervention. Methods A total of 200 patients with type 2 diabetes were selected between January and December 2013. The patients were divide into group of no microvascular disease and group of microvascular lesion according to the complications. Blood lipid, blood glucose, renal function and serum homocysteine were deteced pre-treatment and after 6 months treatment. A total of 100 cases of healthy subjects with physical examination over the same period were selected as control group according to the principle of age and gender matching. Results SBP, DBP, TG, TC, LDL, FBG, 2 hPBG, HbA1, SUN, SCr and HCY in group of no microvascular disease and group of microvascular lesion were significantly higher than that in control group(P<0.01), while HDL were significantly lower(P<0.01); SBP、DBP、SUN、SCr and HCY in group of microvascular lesion were significantly higher than that in group of no microvascular disease(P<0.01); Multi factor Logistic regression analysis showed blood pressure, urea nitrogen, serum creatinine and homocysteine levels are risk factors for microvascular complications in patients with diabetes mellitus; HCY after treatment were significantly lower than that before treatment in group of no microvascular disease and group of microvascular lesion than(P<0.01). Conclusion High homocysteine levels are risk factor of diabetic microvascular disease, and the homocysteine levels can be reduced after treatment.

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更新日期/Last Update: 1900-01-01