[1]吴佩琪,刘春玲,刘再毅,等.钼靶、CT与DCE-MRI评价乳腺癌淋巴结转移的价值[J].南方医科大学学报,2016,(04):493.
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钼靶、CT与DCE-MRI评价乳腺癌淋巴结转移的价值()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2016年04期
页码:
493
栏目:
出版日期:
2016-04-16

文章信息/Info

Title:
Value of mamography, CT and DCE-MRI in detecting axillary lymph node metastasis of breast cancer
作者:
吴佩琪刘春玲刘再毅叶维韬梁长虹
关键词:
乳腺癌淋巴结转移钼靶CTDCE-MRI
Keywords:
breast neoplasms lymph node metastasis mamography CT DCE-MRI
摘要:
目的分析钼靶(MG)、计算机断层扫描(CT)与动态增强磁共振成像(DCE-MRI)对乳腺癌患者腋窝淋巴结有无转移的诊 断价值。方法回顾性分析2014年2月~2015年10月在我院就诊的乳腺癌的女性患者109例,以淋巴结病理检查结果为金标 准,比较和分析MG、CT及DCE-MRI诊断乳腺癌腋窝淋巴结转移(LNM)的灵敏度、特异度、准确度、阳性预测值以及阴性预测 值。结果纳入的乳腺癌患者中,39.4%(43/109)的患者病理确诊LNM。MG诊断LNM的灵敏度、特异度、准确度、阳性预测值 以及阴性预测值分别为:14.0%、84.8%、56.9%、37.5% 和60.0%。CT诊断腋窝LNM的灵敏度、特异度、准确度、阳性预测值以及 阴性预测值分别为:93.0%、57.6%、71.6%、58.8%和92.7%。DCE-MRI诊断腋窝LNM的灵敏度、特异度、准确度、阳性预测值以 及阴性预测值分别为:95.3%、65.2%、77.1%、64.1% 和95.6%。与病理结果相比较,MG、CT、DCE-MRI 的κ值分别为-0.13、 0.459、0.558。MG的特异度高于CT和DCE-MRI,但灵敏度、准确度、阳性预测值、阴性预测值均明显低于CT及DCE-MRI,差 异具有统计学意义。DCE-MRI与CT相比,前者的灵敏度、特异度、准确度、阳性预测值、阴性预测值均高于后者,差异具有统计 学意义(P<0.05)。结论对于乳腺癌腋窝LN 有无转移,DCE-MRI 的诊断效能明显优于CT 和MG,而CT 明显优于MG。 DCE-MRI和CT均可以提供相对较准确的LNM相关情况,在这方面的临床应用价值较高。MG常不能为临床提供可靠的信 息,利用MG判断LNM时必须谨慎,并结合其他检查。
Abstract:
Objective To evaluate the diagnostic value of mammography, computed tomography (CT), and dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) for axillary lymph node staging in breast cancer patients. Methods From February, 2014 to October, 2015, 109 women with breast cancer received examinations with preoperative mamography, CT, and DCE-MRI. The diagnostic sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of the 3 modalities were evaluated using histopathologic assessments as the gold standard. Results In total, 39.4% (43/109) of the patients had axillary lymph node metastasis. The sensitivity, specificity, accuracy, positive predictive value, and negative predictive value of mamography for determining lymph node metastasis were 14.0% , 84.8% , 56.9% , 37.5% and 60.0% , respectively; those of CT were 93.0%, 57.6%, 71.6%,58.8% and 92.7%, and those of DCE-MRI were 95.3%, 65.2%, 77.1%, 64.1% and 95.6%, respectively. Compared with the histopathologic result, the Kappa coefficients of mamography, CT, and DCE-MRI were -0.13, 0.459 and 0.558, respectively. The specificity of mamography was significantly higher (P<0.05), but its sensitivity, accuracy, positive predictive value, and negative predictive value were significantly lower than those of CT and DCE-MRI (P< 0.05). Compared with CT, DCE-MRI had significantly higher sensitivity, specificity, accuracy, positive predictive value, and negative predictive value for diagnosis of lymph node metastasis (P<0.05). Conclusion DCE-MRI has a greater diagnostic power than CT and mammography, and CT has a greater diagnostic power than mammography for axillary lymph node metastasis in breast cancer patients. Mamography alone should be used cautiously for the diagnosis of lymph node metastasis.

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更新日期/Last Update: 1900-01-01