[1]何钕琴,沈淑馨,汪艳,等.急性ST段抬高型心肌梗死患者血清白介素-37表达的时间变化及与C反应蛋白的关系[J].南方医科大学学报,2015,(12):1751.
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急性ST段抬高型心肌梗死患者血清白介素-37表达的时间变化及与C反应蛋白的关系()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2015年12期
页码:
1751
栏目:
出版日期:
2015-12-20

文章信息/Info

Title:
Temporal variation of serum interleukin-37 and its relation with C-reactive protein in
patients with acute ST-segment elevation myocardial infarction
作者:
何钕琴沈淑馨汪艳郭胜存王俊芬宾建平
关键词:
急性ST段抬高型心肌梗死白细胞介素-37C反应蛋白炎症
Keywords:
acute ST-segment elevation myocardial infarction interleukin-37 C-reactive protein inflammation
摘要:
目的探讨急性ST段抬高型心肌梗死(ASTEMI)患者心梗后不同时间血清白细胞介素-37(IL-37)的浓度及其与C反应蛋
白(CRP)的关系。方法筛选2012年6月~2013年12月因胸痛入院,符合纳入标准且不符合排除标准的ASTEMI患者作为心梗
组(n=20),冠脉造影正常的患者作为对照组(n=26)。分别在心梗后第1、3、5、7天清晨抽取患者空腹静脉血。用酶联免疫吸附
法(ELISA法)分别测量患者血清IL-37和CRP的表达水平。结果与对照组相比,IL-37在心梗第1天急速升高,第3天达到高
峰,第5天出现降低,第7天显著降低,呈现先升高后降低的动态变化,与CRP的变化一致;且血清IL-37与CRP具有正相关性
(r=0.63,P<0.05)。结论IL-37可能参与ASTEMI过程中的炎症反应。
Abstract:
Objective To investigate the temporal changes of serum interleukin-37 (IL-37) concentration following acute
ST-segment elevation myocardial infarction (ASTEMI) and the relationship between IL-37 and C-reactive protein (CRP) in
patients with ASTEMI. Methods This analysis was conducted in a cohort of 20 patients with an established diagnosis of
ASTEMI and 26 patients admitted for chest pain but with normal findings in coronary angiography (control) between June
2012 and December 2013. Venous blood was collected at days 1, 3, 5, and 7 after myocardial infarction for measurement of
serum IL-37 and CRP levels using enzyme-linked immunosorbent assay (ELISA). Results Compared with the control group,
the patients in ASTEMI group showed a significant acute elevation of IL-37 level on day 1 following myocardial infarction;
IL-37 level reached the peak on day 3 and began to decrease on day 5, followed by a significant decrease on day 7. The time
course of post-infarction CRP changes was consistent with that of IL-37 variations and showed a positive correlation the latter
(r=0.63, P<0.05). Conclusion IL-37 may participate in the inflammatory responses in ASTEMI.
更新日期/Last Update: 1900-01-01