[1]俞岚,周蕾,武世伍,等.上皮性卵巢癌中CD133与EMT相关因子表达的关系[J].南方医科大学学报,2015,(09):1297.
点击复制

上皮性卵巢癌中CD133与EMT相关因子表达的关系()
分享到:

《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2015年09期
页码:
1297
栏目:
出版日期:
2015-09-15

文章信息/Info

Title:
Expressions of CD133, E-cadherin, and Snail in epithelial ovarian cancer and their clinicopathologic
and prognostic implications
作者:
俞岚周蕾武世伍宋文庆承泽农郭冰沁
关键词:
上皮性卵巢癌CD133SnailE-cadherin预后
Keywords:
epithelial ovarian cancer CD133 snail E-cadherin prognosis
摘要:
目的探讨上皮性卵巢癌(Epithelial ovarian cancer, EOC)中CD133 蛋白及上皮-间质转化(Epithelial mesenchymal
transition, EMT)相关因子Snail、E-cadherin 蛋白表达的关系及其功能意义。方法采用免疫组织化学ElivisionTM plus 法检测
150 例EOC和50 例良性上皮性卵巢肿瘤中CD133、Snail 和E-cadherin 蛋白的表达情况。结果良性上皮性卵巢肿瘤组织中
CD133、Snail和E-cadherin蛋白的表达阳性率分别为10%、8.0%和70%,在EOC组织中3者表达分别为58.7%、60.7%和32.7%,
差异有统计学意义(P<0.05)。CD133、Snail 和E-cadherin 的表达与EOC的腹腔脏器和淋巴结转移以及FIGO 分期有关(P<
0.01);E-cadherin蛋白的表达与Snail及CD133 蛋白的表达均呈负相关关系(r分别为-0.545和-0.570,P均<0.01),CD133蛋白的
表达与Snail蛋白的表达呈正相关关系(r=0.599,P<0.01)。Kaplan-Meier生存分析表明,CD133和Snail的过表达均与患者的生
存率有关,阳性表达的患者生存率明显低于阴性者(P<0.05);而随着E-cadherin蛋白表达水平的降低EOC患者生存率明显下
降(P<0.05)。多因素分析表明FIGO分期、CD133、Snail 和E-cadherin 的表达是影响EOC根治术后患者预后的独立因素(P<
0.05)。结论CD133和Snail表达的升高以及E-cadherin表达的降低与EOC的侵袭、转移和预后等因素相关,这些指标的联合
检测有可能作为评估EOC患者临床预后的重要指标。
Abstract:
Objective To explore expressions of CD133, E-cadherin and Snail in hu¬man epithelial ovarian cancer (EOC) and
elucidate their relationship with the clinicopathologic features and prognosis of the patients. Methods The expression of
CD133, E-cadherin and Snail were detected by immunohistochemical staining in 150 specimens of EOC and 50 specimens of
benign ovarian epithelial tumor tissues. Results The positivity rates of CD133, E-cadherin and Snail protein in EOC were
58.7%, 60.7% and 32.7%, respectively, significantly different from the rates in benign epithelial tumor tissues (10%, 8.0%, and
70% , respectively; P<0.05). The expressions of CD133, E-cadherin and Snail in EOC were significantly correlated with
abdominal organ and lymphnode metastases and FIGO stage (P<0.01). E-cadherin expression was inversely correlated with
Snail and CD133 expression (r=-0.545 and -0.570, P<0.01), and the latter two were positively correlated (r=0.599, P<0.01).
Overexpressions of CD133 and Snail and a decreased expression of E-cadherin were all related to a poor prognosis of the
patients (P<0.05). FIGO stage and expressions of CD133, E-cadherin and Snail were all independent prognostic factors of EOC
(P<0.05). Conclusion The expressions of CD133, E-cadherin and Snail are related to lymph node metastasis, clinical stage, and
prognosis of EOC. Combined detection of these indexes provides important evidence for predicting the progression and
prognosis of EOC.

相似文献/References:

[1]田平阁,周春平,张超,等.靶向肿瘤干细胞标记CD133特异性结合肽的筛选和初步鉴定[J].南方医科大学学报,2011,(05):761.
[2]钟立业,杜欣,耿素霞,等.CD133 在骨髓增生异常综合征患者中的表达及临床意义[J].南方医科大学学报,2011,(05):854.
[3]陈文晟,马磊,胡晓晔,等.大肠癌细胞中Oct4与CD133的表达及意义[J].南方医科大学学报,2011,(08):1434.
[4]兰曦,王勇,曹姝,等.RNA干扰抑制CD133 表达对CD133+肝癌干细胞增殖和化疗敏感性的影响[J].南方医科大学学报,2012,(12):1741.
[5]黎丽旋,张珊珊,梁芬芬,等.无血清培养CD133+Colo205大肠癌细胞可高表达ALDH1[J].南方医科大学学报,2013,(06):889.
[6]俞岚,武世伍,周蕾,等.膀胱尿路上皮癌中CD133、CD82/KAI1的表达及其与血管生成拟态的关系[J].南方医科大学学报,2013,(09):1336.
[7]陆国玉,吴晓飞,周蕾,等.CD133和CD44在胃腺癌中的表达及其与E-cadherin的关系[J].南方医科大学学报,2013,(11):1632.
[8]张珊珊,黎丽旋,黄载伟,等.基因芯片技术筛选和鉴定CD133+CD200+大肠癌干细胞相关基因[J].南方医科大学学报,2013,(12):1787.
[9]陈兴月,侯妍利,段丽群,等.131I-CD133mAb联合顺铂在体内外有效抑制人肝癌细胞的生长[J].南方医科大学学报,2014,(07):934.
[10]周蕾,武世伍,俞岚,等.非小细胞肺癌中CD133和Notch1的表达及其临床病理意义[J].南方医科大学学报,2015,(02):196.

更新日期/Last Update: 1900-01-01