[1]陈建发,岳志强,傅明,等.新辅助化疗前Apollon在乳腺癌组织中的表达及意义[J].南方医科大学学报,2015,(08):1201.
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新辅助化疗前Apollon在乳腺癌组织中的表达及意义()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2015年08期
页码:
1201
栏目:
出版日期:
2015-07-26

文章信息/Info

Title:
Immunoexpression of apollon in breast cancer tissues before neoadjuvant chemotherapy
and its clinical significance
作者:
陈建发岳志强傅明莫友周淑蓉
关键词:
apollon免疫组化表达乳腺癌病理完全缓解新辅助化疗活检
Keywords:
apollon immunoexpression breast cancer pathological complete response neoadjuvant chemotherapy biopsy
摘要:
目的调查乳腺癌标本中apollon免疫组化表达是否能够预测新辅助化疗(NAC)后的病理完全缓解(pCR)。方法采用免
疫组化技术检测124例乳腺癌患者活检组织内的apollon、Her-2、ER(雌激素受体)及PR(孕激素受体)表达。通过实体肿瘤反应
评价标准(RECIST)评价NAC疗效。分析不同型乳腺癌的pCR率。分析apollon状态与Her-2状态、ER状态、PR状态、淋巴结状
态及肿瘤大小之间的相关性。采用免疫组化技术比较了NAC前后乳腺癌切片内apollon的表达变化。结果pCR率为18.5%
(23/124)并与apollon、ER及PR表达关系密切:apollon 阴性>apollon 阳性、ER阴性>ER阳性及PR阴性>PR阳性。Apollon 与
Her-2状态、ER状态、PR状态及淋巴结状态相关。另外,化疗显著下调了肿瘤细胞内apollon的表达。结论Apollon阴性表达可
能是pCR的一个预测因子。
Abstract:
Objective To investigate whether apollon immunoexpression in breast cancer tissues helps to predict pathological
complete response (pCR) after neoadjuvant chemotherapy (NAC). Methods The expressions of Apollon, Her-2, estrogen
receptor (ER) and progesterone receptor (PR) were detected immunohistochemically in biopsy tissues from 124 breast cancer
patients. The clinical responses to NAC were evaluated in line with the response evaluation criteria in solid tumors (RECIST).
The pCR rate was analyzed for different types of breast cancer. The correlations between Apollon status with Her-2, ER, PR,
lymph node status and tumor size were analyzed. Immunohistochemistry was used to compared the changes in Apollon
expression in the breast cancer tissues before and after NAC. Results The pCR rate was 18.5% (23/124) in these patients.
Negative expressions of apollon, ER and PR were all associated with a higher pCR rate after NAC. Apollon was significantly
correlated with Her-2, ER, PR and lymph node involvement. Chemotherapy significantly down-regulated apollon expression
in the tumor cells. Conclusion Anegative apollon expression might be a predictor of pCR in patients with breast cancer.

相似文献/References:

[1]陈建发,李宇华,陈引香,等.Apollon siRNA提高肝癌细胞化疗敏感性的实验研究[J].南方医科大学学报,2011,(10):1701.

更新日期/Last Update: 1900-01-01