[1]熊思敏,赵 娜,裘宇容,等.MASP2在小儿上呼吸道感染中的意义[J].南方医科大学学报,2015,(06):888.
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MASP2在小儿上呼吸道感染中的意义()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2015年06期
页码:
888
栏目:
出版日期:
2015-06-15

文章信息/Info

Title:
Plasma levels of mannan-binding lectin-associated serine protease 2 in children with
upper respiratory tract infection
作者:
熊思敏赵 娜裘宇容张丽芸左大明陈政良
关键词:
甘露聚糖结合凝集素相关丝氨酸蛋白酶2上呼吸道感染C反应蛋白白细胞计数
Keywords:
mannan-binding lectin-associated serine protease 2 upper respiratory tract infection C reactive protein whiteblood cell count
摘要:
目的探讨血浆甘露聚糖结合凝集素(MBL)相关丝氨酸蛋白酶2(MASP2)水平在儿童上呼吸道感染(上感)中的意义。方
法取103 例上感患儿和35 例健康体检儿童作为研究对象,测定其血浆MASP2 和C反应蛋白(CRP)浓度并进行白细胞计数
(WBC)。根据CRP和WBC值、感染不同时期及有无治疗,上感儿童分为CRP升高组(n=48)与正常组(n=54)、WBC升高组(n=
61)与正常组(n=40)、感染早期未用药组(n=68)与感染中后期已用药组(n=35),对各组资料进行统计学分析。结果上感组
MASP2浓度显著高于对照组(P<0.001),CRP升高组血浆MASP2浓度与CRP值正相关(r=0.310,P<0.05),WBC升高组MASP2
水平与WBC值显著正相关(r=0.392,P<0.01),感染早期未用药组MASP2 浓度显著高于感染中后期已用药组(P<0.01),
MASP2、CRP、MBL2基因具有共同的转录因子HNF-4α结合位点。结论MASP2蛋白可能为急性期蛋白,血浆MASP2水平可作
为辅助诊断小儿上感的一个参考指标。
Abstract:
Objective To explore the significance of plasma levels of mannan-binding lectin (MBL)-associated serine protease 2
(MASP2) in children with upper respiratory tract infection (URTI). Methods A total of 103 children with URTI and 35 healthy
children were examined for plasma levels of MASP2 and C-reactive protein (CRP). According to CRP levels, white blood cell
count (WBC), stage of infection, and administration of treatments, the children with URTI were divided into the elevated CRP
group (n=48) and the normal CRP group (n=54), elevated WBC group (n=61) and normal WBC group (n=40), the early stage of
infection without treatment group (n=68) and mid-late stage of infection with treatment group (n=35). Results Plasma MASP2
levels was significantly higher in URTI group than in the healthy control group (P<0.001) and showed a close correlation with
age (r=0.302, P<0.01). Plasma MASP2 level was significantly correlated with CRP level in elevated CRP group (r=0.310, P<0.05)
but not in normal CRP group (P>0.05), correlated with WBC in elevated WBC group (r=0.392, P<0.01) but not in normal WBC
group (P>0.05), and was significantly higher in early stage infection without treatment group than in mid-late stage of infection
with treatment group (P<0.01). MASP2, MBL2 and CRP genes had a common binding site for the transcription factor HNF-4α.
Conclusion MASP2 may be an acute-phase protein, and its plasma level might serve as a new reference index in the diagnosis
of URTI in children.
更新日期/Last Update: 1900-01-01