[1]慕庆玲,肖松舒,万亚军.以肾脏自发破裂为临床表现的侵袭性葡萄胎1例报道[J].南方医科大学学报,2015,(02):309.
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以肾脏自发破裂为临床表现的侵袭性葡萄胎1例报道()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2015年02期
页码:
309
栏目:
出版日期:
2015-03-02

文章信息/Info

Title:
Spontaneous renal hemorrhage caused by invasive mole: a case report
作者:
慕庆玲肖松舒万亚军
关键词:
侵袭性葡萄胎转移灶化疗
Keywords:
invasive mole metastasis renal brain chemotherapy
摘要:
目的探讨妊娠滋养细胞肿瘤肾转移的临床表现、影像学表现及治疗方案。方法回顾性分析一例以肾脏自发破裂出血为
临床表现的侵袭性葡萄胎患者的病史、辅助检查及诊治经过。结果治疗前患者滋养细胞肿瘤病灶全身多处转移,经依托泊苷、
甲氨喋呤、放线菌素-D、长春新碱及环磷酰胺联合鞘内化疗及手术切除子宫及左肾后β-人绒毛膜促性腺激素(Beta human
chorionic gonadotrophin, β-HCG)降至正常,影像学检查原转移病灶均吸收好转。结论妊娠滋养细胞肿瘤全身转移引起转移
灶出血,该疾病对以上化疗敏感,适时手术可提高患者的治疗效果。
Abstract:
Gestational trophoblastic tumors (GTTs) are malignant lesions that often cause abnormal genital bleeding and may
present with hemoptysis, intraperitoneal bleeding or acute neurologic deficits. GTTs are generally highly chemosensitive with
more favorable outcomes than other comparable malignancies. Here we report a rare case of invasive mole (FIGO stage IV,
WHO score16) presenting with renal subcapsular hematoma due to bleeding renal metastasis. The patient had a pretreatment
β-human chorionic gonadotrophin (β-HCG) level of 462 047 mIU/ml and received combined chemotherapy with etoposide,
methotrexate, actinomycin-D, cyclophosphamide and vincristine with also adjuvant surgeries including hysterectomy and
nephrectomy. The patient recovered well and the tumor has remained in complete remission for one year and a half.
更新日期/Last Update: 1900-01-01