[1]何朝生,符霞,梁馨苓,等.连续性血液净化治疗体外循环堵管风险积分模型的构建[J].南方医科大学学报,2015,(02):272.
点击复制

连续性血液净化治疗体外循环堵管风险积分模型的构建()
分享到:

《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2015年02期
页码:
272
栏目:
出版日期:
2015-03-02

文章信息/Info

Title:
A prognostic model for predicting extracorporeal circuit clotting in patients with
continuous renal replacement therapy
作者:
何朝生符霞梁馨苓宋利史伟
关键词:
连续性血液净化体外循环凝血积分模型
Keywords:
continuous blood purification extracorporeal circuit clotting integral model
摘要:
目的构建24 h连续性血液净化治疗患者的体外循环堵管风险积分模型。方法研究对象为425例连续性血液净化治疗的
患者,其中302例用于建立体外循环堵管风险积分模型,103例用来验证该模型,观察终点为CRRT体外循环管路堵塞。所有数
据采用SPSS 17.0软件包进行统计分析。结果24 h CRRT体外循环堵塞的风险积分模型的风险评分为0~5分。模型积分系统
的ROC曲线下面积0.790(95% CI 0.719~0.826),P<0.001,可较好地判断24 h内CRRT体外循环是否会堵塞。检验结果显示,
CRRT体外循环堵管预测积分模型的拟合度良好,预测堵管的发生率与实际堵管发生率无统计学差异(R2=0.301,P=0.232)。验
证组病例中低危、中危和高危三组体外循环管路的生存时间有显著性差异(P<0.05)。结论连续性血液净化治疗体外循环堵管
风险积分模型,包括血流量不足、无抗凝剂治疗、HCT、LAC和APTT值等可以预测治疗过程中可能发生的堵管问题。根据预测
可及时提前进行干预处理,减少了意外不良事件的发生。
Abstract:
Objective To establish a prognostic model for predicting extracorporeal circulation clotting in patients with
continuous renal replacement therapy(CRRT). Methods 425 patients with CRRT were involved in the study. We built a
predictive risk model of extracorporeal blood clotting with the 302 participants, and 103 participants were used to validate the
model. The primary endpoint of CRRT was extracorporeal circulation pipe blockage. Results We used a score of 0-5 point
evaluating system to predict the risk of 24 hours CRRT integral model of cardiopulmonary bypass clogging. The area under
the CRRT predictive model of cardiopulmonary bypass clogging integral system ROC curve was 0.790 (95% CI 0.719-0.826)(P<
0.001). The evaluating system can determine the blockage of 24 hours CRRT extracorporeal circulation. The results showed that
CRRT extracorporeal plugging prediction fitted the integral model and could predict the chance of plugging. The actual
plugging rate showed no significant difference from the predicted rate (R2=0.301, P=0.232). The cardiopulmonary pipe survival
time between the 3 groups(low risk, intermediate risk, and high risk) showed a significant difference (P<0.05). Conclusion We
established a continuity extracorporeal blood purification plugging risk score model, to predict plugging risks during CRRT
treatment.

相似文献/References:

[1]吴华,张国华,王武军,等.不同超滤膜对体外循环术后呼吸功能的影响[J].南方医科大学学报,2004,(07):802.
 WU Hua,ZHANG Guo-hua,WANG Wu-jun,et al.Ultrafiltration with different membranes and respiratory function after cardiopulmonary bypass[J].Journal of Southern Medical University,2004,(02):802.
[2]汪芳俊,陈斌,刘洋,等.乌拉地尔联合酚妥拉明控制体外循环期间高血压的效果[J].南方医科大学学报,2014,(09):1342.
[3]陆华,张卫达,马涛,等.常温非体外循环进行弓部优先重建在A型夹层全弓置换中的应用[J].南方医科大学学报,2013,(01):152.
[4]莫文魁,何良勇,陈群清,等.兔脑栓塞急性期体外循环模型的建立及临床意义[J].南方医科大学学报,2013,(11):1652.
[5]李智博,温德良,刘卫江,等.连续性血液净化对肺外源ARDS患者肺血管外肺水及呼吸功能的影响[J].南方医科大学学报,2015,(07):1047.
[6]许志扬,江国英,林世清,等.N-乙酰半胱氨酸对体外循环大鼠肠损伤的影响[J].南方医科大学学报,2014,(08):1171.
[7]鲍权,洪小杨,唐靖,等.改良兔体外循环急性肺损伤模型的建立[J].南方医科大学学报,2017,(06):797.
[8]曹舸,张尔永.右美托咪定对体外循环缺血再灌注损伤肺组织保护作用的相关信号通路[J].南方医科大学学报,2019,(08):980.[doi:10.12122/j.issn.1673-4254.2019.08.16]

更新日期/Last Update: 1900-01-01