[1]胡晨,张世卿,金晓艳,等.梅连消渴胶囊联合二甲双胍对糖尿病大鼠胰岛细胞及血糖水平的影响[J].南方医科大学学报,2014,(09):1365.
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梅连消渴胶囊联合二甲双胍对糖尿病大鼠胰岛细胞及血糖水平的影响()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2014年09期
页码:
1365
栏目:
出版日期:
2014-09-15

文章信息/Info

Title:
Meilian Xiaoke capsule combined with metformin for protecting islet cells and lowering
blood glucose in diabetic rats
作者:
胡晨张世卿金晓艳佟丽
关键词:
实验性糖尿病梅连消渴胶囊二甲双胍血糖胰岛细胞
Keywords:
diabetes mellitus Meilian Xiaoke capsule metformin islet cells
摘要:
目的观察中药复方梅连消渴胶囊联合二甲双胍对实验性糖尿病大鼠血糖水平及胰岛细胞的保护作用。方法以高脂高
糖联合链脲佐菌素(STZ)复制大鼠Ⅱ型糖尿病模型,分别以低剂量二甲双胍和梅连消渴胶囊及二者联合用药灌胃给药4周,测
定实验性糖尿病大鼠血糖水平;以HE染色观察胰岛病理改变;以醛复红染色计算胰岛β细胞数量。结果大鼠分别给予低剂量
二甲双胍及梅连消渴胶囊2、4周后,空腹血糖水平及葡萄糖耐量无显著变化;二者联合给药2、4周后,大鼠血糖水平、糖化血红
蛋白水平显著降低,葡萄糖耐量显著改善。同时,胰岛β细胞数量增加,胰岛组织病理改变减轻。结论梅连消渴胶囊与二甲双
胍联合用药后,糖尿病大鼠血糖水平显著降低,对损伤的胰岛细胞有保护和修复作用。
Abstract:
Objective To study the effects of Meilian Xiaoke capsule (a traditional Chinese medicinal preparation) combined with
metformin for protecting islet cells and lowering blood glucose in diabetic rats. Methods Rat models with type 2 diabetes,
established by high-fat and high-glucose diet combined with streptozotocin (STZ) injection, were treated with a low dose of
metformin, Meilian Xiaoke capsule, or both for 4 weeks by gavage. Blood glucose level was tested in the rats, and islet
pathologies and changes in islet β cell number after the treatment were observed with HE staining and aldehyde fuchsin
staining, respectively. Results Treatment with metformin or Meilian Xiaoke capsule alone for 2 or 4 weeks did not produce
significant improvement of blood glucose in the diabetic rats. Their combined treatment for 4 weeks resulted in significantly
lowered blood glucose level and improved glucose tolerance with also obviously increased islet β cell number and lessened
islet pathologies. Conclusion Meilian Xiaoke capsule and metformin show a synergistic effect to significantly enhance the
therapeutic effect in rats with type 2 diabetes.
更新日期/Last Update: 1900-01-01