[1]郭牟莹,张水兴,许明智,等.首发抑郁症患者的静息态功能成像[J].南方医科大学学报,2014,(09):1277.

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首发抑郁症患者的静息态功能成像()

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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

Title:: Resting-state functional magnetic resonance imaging of first-onset major depressive
disorder: analysis of 18 cases

Keywords:: major depressive disorders; magnetic resonance imaging; resting-state

摘要:: 目的运用REHO技术探讨首发抑郁症患者静息态脑功能的变化。方法采用GE 3.0T磁共振成像仪对18例首发抑郁症
患者和20例性别、年龄相匹配的正常志愿者进行静息态功能成像（fMRI）检查，排除全脑器质性病变，运用DPARSF、REST分析
软件进行全脑分析。结果抑郁症患者与正常志愿者比较，抑郁症患者存在多个与认知及情绪控制相关脑区的自发神经活动异
常，其中在左侧后扣带回、双侧颞下回、双侧颞上回、左侧到岛盖部额下回、左侧海马、左侧中央后回、左侧角回、右侧杏仁核、右
侧眶内额上回、右侧补充运动区、右侧小脑后叶局部一致性减低（P<0.05）。结论首发抑郁症患者静息态脑功能存在部分脑功
能异常。这些脑区均与认知和情绪的控制密切相关。

Abstract:: Objective To investigate the changes in brain regional homogeneity in first-onset major depressive disorders
(MDDs) using resting-state functional magnetic resonance imaging (fMRI). Methods Eighteen patients with first-onset MDDs
and twenty gender- and age-matched healthy controls underwent resting-state fMRI scans to compare the regional
homogeneities of the brain regions. Results Compared with the normal controls, the patients with MDDs showed significantly
decreased regional homogeneity in the left posterior cingulated gyrus, bilateral inferior temporal gyrus, bilateral superior
temporal gyrus, left inferior frontal gyrus, left hippocampa gyrus, left posterior central gyrus, left angular gyrus, right
amygdala, right orbital frontal gyrus, right supplementary motor area, and right cerebellar lobe. Conclusion Patients with
first-onset MDDs have dysfunctions in the brain regions closed related with cognition and emotional control.

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更新日期/Last Update: 1900-01-01