[1]陈艳丽,李伟琴.儿童川崎病丙种球蛋白治疗前后血清25-羟维生素D3及白介素6水平的变化及意义[J].南方医科大学学报,2014,(08):1230.
点击复制

儿童川崎病丙种球蛋白治疗前后血清25-羟维生素D3及白介素6水平的变化及意义()
分享到:

《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2014年08期
页码:
1230
栏目:
出版日期:
2014-08-15

文章信息/Info

Title:
Changes of serum 25-hydroxyvitamin D3 and interleukin-6 after treatment with
intravenous immunoglobulins in children with Kawasaki disease
作者:
陈艳丽李伟琴
关键词:
川崎病25-(OH)D3IL-6
Keywords:
Kawasaki disease 25-hydroxyvitamin D3 interleukin-6
摘要:
目的通过检测川崎病(KD)患儿丙种球蛋白治疗前后血清25-羟维生素D3[(25-(OH)D3)]及白介素6(IL-6)水平,探讨其
与川崎病的关系。方法选取在我院住院的KD患儿35例,检测丙种球蛋白治疗前后血清25-(OH)D3和IL-6水平,并选取25例
呼吸道感染发热患儿作为发热对照组,25例正常儿童作为正常对照组,分别检测其血清25-(OH)D3和IL-6值,并对各组进行比
较。结果KD治疗前25-(OH)D3水平:正常儿童较发热儿童高(P=0.025);KD患儿较正常儿童高(P=0.023),均有统计学意义;
血清IL-6水平:发热儿童虽较正常儿童高(P=0.4),但差异无统计学意义,KD患儿较发热儿童高(P=0.000),差异有统计学意义;
将25-(OH)D3与IL-6 水平进行相关分析,r=0.9,P=0.000。血清25-(OH)D3水平在丙种球蛋白治疗后较治疗前明显升高(P=
0.012),差异有统计学意义;血清IL-6水平在丙种球蛋白治疗后较治疗前降低(P=0.325),但差异无统计学意义;治疗后血清25-
(OH)D3与IL-6 水平无相关性(r=0.18,P=0.4)。结论KD 患儿治疗前血清25-(OH)D3与IL-6 水平呈正相关,治疗后无明显相
关。25-(OH)D3可能参与KD的发病,可作为KD的潜在治疗靶点。
Abstract:
Objective To explore the changes of serum 25-hydroxyvitamin D3 [25-(OH)D3] and interleukin-6 (IL-6) in children
with Kawasaki disease (KD) after treatment with intravenous immunoglobulins (IVIG) and analyze their clinical implications.
Methods Thirty-five children with KD (26 boys and 9 girls) were examined for serum 25-(OH)D3 and IL-6 levels before and
after IVIG treatment using enzyme linked immunosorbent assay (ELISA), with 25 febrile children with respiratory tract
infections and 25 healthy children as controls. Results Serum 25-(OH)D3 levels were significantly higher in healthy children
than in febrile children (P=0.025), and was even higher in children with KD before IVIG treatment (P=0.023). Serum IL-6 levels
were similar between healthy and febrile children (P=0.4), but significantly elevated in KD children (P=0.000). Serum 25-(OH)
D3 level was positive correlated with serum IL-6 level in KD children before treatment (r=0.9, P=0.000). In KD children after
IVIG treatment, serum 25-(OH)D3 level was significantly increased (P=0.012) and serum IL-6 levels slightly decreased (P=0.325)
without showing any correlations (r=0.18, P=0.4). Conclusion Serum 25-(OH)D3 level is positively correlated with serum IL-6
level in KD children before IVIG treatment but not after the treatment,. 25(OH)D3 may participate in the pathogenesis of KD
and potentially serves as the therapeutic target for KD.

相似文献/References:

[1]龙振荣,刘卓华,李彬.彩色多普勒超声心动图在川崎病心脏病变中的应用价值[J].南方医科大学学报,2004,(12):1455.
 LONG Zhen-rong,LIU Zhuo-hua,LI Bin.Value of Doppler color echocardiography in diagnosis of Kawasaki disease with cardiac involvement[J].Journal of Southern Medical University,2004,(08):1455.

更新日期/Last Update: 1900-01-01