[1]张鑫,孙学华,周振华,等.SRC同源区2结构域蛋白基因多态性与慢性乙型肝炎易感性的关系[J].南方医科大学学报,2014,(04):468.
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SRC同源区2结构域蛋白基因多态性与慢性乙型肝炎易感性的关系()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2014年04期
页码:
468
栏目:
出版日期:
2014-04-15

文章信息/Info

Title:
Association between CISH polymorphisms and susceptibility to chronic hepatitis B in
Chinese Han population
作者:
张鑫孙学华周振华李曼高月求
关键词:
SRC同源区2结构域蛋白慢性乙型肝炎单核苷酸多态性易感性
Keywords:
cytokine-inducible src homology 2 domain protein chronic hepatitis B single nucleotide polymorphismssusceptibility
摘要:
目的探讨中国汉族人群细胞因子可诱导的SRC同源区2结构域蛋白(CISH)基因rs414171位点与慢性乙型肝炎易感性的关系。
方法利用Sequenom MassArray-IPLEX SNP分型技术,对233例慢性乙型肝炎患者和148例健康对照者CISH基因的rs414171位点
进行基因分型,采用χ2检验方法统计分析病例组与对照组间等位基因频率和基因型频率的差异。结果病例组和对照组的
rs414171位点的基因型分布均符合Hardy-Weinberg平衡定律(P>0.05)。该位点的等位基因频率和基因型频率在病例组和对照
组中的分布无统计学差异(P>0.05)。结论CISH基因rs414171位点的多态性与中国汉族人慢性乙型肝炎易感性无明显相关性。
Abstract:
Objective To investigate the association between rs414171 single nucleotide polymorphisms (SNP) of cytokineinducible
src homology 2 domain protein (CISH) and the susceptibility to chronic hepatitis B. Methods A total of 233 Chinese
Han patients with chronic hepatitis B and 148 age- and sex-matched healthy controls were enrolled in this case-control study.
The SNP rs414171 was genotyped by Sequenom MassArray-IPLEX to analyze the relationship between rs414171 and chronic
hepatitis B. Results The distribution of SNP rs414171 allele and genotype frequencies showed no significant difference
between the patients and healthy controls (P>0.05). Conclusion CISH rs414171 is not significantly associated with the
susceptibility to chronic hepatitis B in Chinese Han population.

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更新日期/Last Update: 1900-01-01