[1]郭洁洁,王闯,王钦文.神经肽VGF作为新型抗抑郁调节因子的研究进展[J].南方医科大学学报,2014,(02):279.
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神经肽VGF作为新型抗抑郁调节因子的研究进展()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2014年02期
页码:
279
栏目:
出版日期:
2014-02-15

文章信息/Info

Title:
Research process of the neuropeptide VGF as a novel antidepressant regulatory factor
作者:
郭洁洁王闯王钦文
关键词:
抑郁症神经肽VGF神经发生神经营养突触活动
Keywords:
depression neuropeptide VGF neurogenesis neurotrophic synaptic activity
摘要:
抑郁症作为主要的致残疾病预计到2020年将成为全球第2大疾病负担。随着研究的深入,该病的发病机制也从“单胺类
递质假说”向“神经营养假说”及“增强神经发生作为抗抑郁手段”的认识转变,为发现新型抗抑郁调节因子带来了希望。大量研
究表明神经肽VGF参与海马神经发生及神经可塑性的的调节,对神经元的增殖与存活功能发挥着重要调节作用,表明神经肽
VGF有望成为一种新型抗抑郁调节因子。本文将对近年来神经肽VGF在神经发生、神经营养及突触活动的调控机制进行综
述,进一步为研究以神经肽VGF为靶标的新型抗抑郁药物提供了新思路。
Abstract:
As a major cause of disability, depression is expected to become the second highest burden of disease worldwide by
the year 2020. The shift of research in depression from monoamine hypothesis to the realm of neurotrophic hypothesis, neural
plasticity hypothesis, and enhancing neurogenesis as an antidepressant-like agent brings about crucial insights to find novel
mediator of antidepressant activity. Studies have shown that the neuropeptide VGF participates in the regulation of
hippocampal neurogenesis and neuroplasticity and also plays an important role in the regulation of neuronal proliferation and
survival, suggesting that the neuropeptide VGF may be a novel regulator in antidepressant treatment. The authors review the
latest progress in the regulatory mechanisms of neurpeptide VGF on neurogenesis, neurotrophic and synaptic activity in
depression. Further understanding of the role of neuropeptide VGF in depression can identify novel targets for
pharmacological interventions.

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更新日期/Last Update: 1900-01-01