[1]严婷,李玲玲,王怀明,等.2型糖尿病患者脂肪细胞因子与代谢综合征的关系[J].南方医科大学学报,2014,(02):275.
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2型糖尿病患者脂肪细胞因子与代谢综合征的关系()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2014年02期
页码:
275
栏目:
出版日期:
2014-02-15

文章信息/Info

Title:
Correlation between adipocytokines levels and metabolic syndrome in type 2 diabetes
mellitus
作者:
严婷李玲玲王怀明王娇蔡德鸿
关键词:
代谢综合征脂肪细胞因子内脏脂肪组织源性丝氨酸蛋白酶抑制剂血清脂联素白介素6
Keywords:
metabolic syndrome adipocytokine visceral adipose tissue-derived serine protease inhibitor adiponectininterleukin-6
摘要:
目的比较2型糖尿病合并代谢综合征患者及2型糖尿病无代谢综合征患者体内脂联素、内脏脂肪组织源性丝氨酸蛋白酶
抑制剂、IL-6的水平,探讨ADP、丝氨酸蛋白酶抑制剂、IL-6与代谢综合征的关系。方法68例新诊断T2DM患者分成两组:2型
糖尿病合并代谢综合征组(M组)51例及2型糖尿病无代谢综合征组(F组)17例。测定各组空腹血清IL-6、脂联素、内脏脂肪组
织源性丝氨酸蛋白酶抑制剂、血糖、血脂、糖化血红蛋白(HbA1C)、胰岛素(INS)、胰岛素抵抗水平(HOMA-IR)、体质量(BMI)、
腰臀比(W/H)等。结果M组BMI、HbA1c、空腹血糖(FBG)、空腹胰岛素(FINS),胰岛素抵抗(HOMA-IR),甘油三酯(TG)、总
胆固醇(TC)、血管收缩压(SBP)等水平显著高于F组(P<0.05或0.01)。M组的IL-6 显著高于F组,脂联素显著低于F组。丝氨
酸蛋白酶抑制剂两组间无显著差异。脂联素与TG(r=-0.30,P=0.02)呈明显正相关,与BMI(r=-0.47,P=0.39)、HOMA-IR
(r=-0.30,P=0.03)呈明显负相关(P<0.05)。vaspin与HOMA-IR(r=0.347,P=0.02)呈明显正相关(P<0.05),与HDL-L(r=-0.45,P=
0.01)呈明显负相关(P<0.05)。IL-6 与LDL-L(r=0.54,P=0.00)呈明显正相关(P<0.05),与HDL-L(r=-0.45,P=0.01)呈明显负相
关(P<0.05)。结论血清脂联素、IL-6浓度与代谢综合征密切相关,丝氨酸蛋白酶抑制剂与代谢综合征的关系尚待研究。
Abstract:
Objective To study the correlation between adipocytokines levels and metabolic syndrome (MS) in patients with
newly diagnosed type 2 diabetes mellitus (T2DM). Methods Sixty-eight patients with newly diagnosed T2DM, including 51
cases with MS and 17 without MS, were examined for blood pressure (BP), fasting blood glucose (FBG), fasting insulin (FINS),
insulin resistance index (IRI), waist to hip ratio (W/H), body mass index (BMI), and serum dipocytokine levels (IL-6, vaspin,
and adiponectin). Results The diabeitc patients with MS had higher BMI, HbA1c, FBG, FINS, IRI, TG, TC, and SBP than those
without MS. Serum IL-6 level was higher but adiponectin level was lower in patients with MS than in those without MS. There
was no significant difference in vispin level between the two groups. Adiponectin level was positively correlated with TG
(r=-0.30, P=0.02) and inversely with BMI (r=-0.47, P=0.39) and HOMA-IR (r=-0.30, P=0.03); vispin level was positively correlated
with HOMA-IR (r=0.347, P=0.02) and inversely with HDL-L (r=-0.45, P=0.01); IL-6 level was positively correlated with LDL-L
(r=0.18, P=0.25) and inversely with HDL-L (r=-0.45, P=0.01). Conclusion Adiponectin and IL-6 levels are closely related to MS,
but the relationship between vispin and MS needs further invesitgation.

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更新日期/Last Update: 1900-01-01