[1]刘欣,王节,张舜欣,等.北京地区临床无前列腺癌人群年龄相关性前列腺特异性抗原的参考范围[J].南方医科大学学报,2013,(11):1704.
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北京地区临床无前列腺癌人群年龄相关性前列腺特异性抗原的参考范围()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2013年11期
页码:
1704
栏目:
出版日期:
2013-11-15

文章信息/Info

Title:
Age-related reference ranges of serum prostate-specific antigen in men free of prostate cancer in Beijing
作者:
刘欣; 王节; 张舜欣; 林倩
关键词:
年龄; 前列腺癌; 前列腺特异性抗原
Keywords:
age;  prostate cancer;  prostate-specific antigen
摘要:
目的探讨前列腺特异性抗原（PSA）在不同年龄段临床无前列腺癌人群中的参考值范围，以提高PSA在前列腺癌筛查中
的诊断准确性。方法自2010年4月~2011年10月来我院进行正常健康查体的1611例成年男性为参与者。所有参与者均接受
前列腺特异性抗原抽血检查、肛门指检（DRE）及经直肠超声（TRUS）检查。以上三项检查任何两项出现异常者，行前列腺穿刺
活检。最终共有1572位无前列腺癌者纳入本研究。按年龄分为5组，40~49岁、50~59岁、60~69岁、70~79岁、≥80岁。结果中
位数（95%分位数）分别为：40~49岁为0.506（1.565），50~59岁为1.04（2.920），60~69岁为1.16（4.113），70~79岁为1.34（5.561），
80 岁以上为2.975（7.285）。按年龄从低至高各组的25%分位数至75%分位数分别为0.343~0.923，0.663~1.580，0.693~2.203，
0.789~2.368、1.188~4.295。前列腺特异性抗原与年龄呈正相关（r=0.314，P<0.001）。结论在前列腺癌筛查时，对不同年龄段的
人使用不同的血清PSA参考值范围，能提高其诊断准确率，但不同民族和地区应选择适合本地区人群的血清PSA参考值。
Abstract:
Objective To determine the age-related normal ranges of serum prostate-specific antigen (PSA) level in men free of
prostate cancer in Beijing. Methods Form April 2010 to October 2011, 1611 healthy men undergoing routine physical
examinations in our hospital were enrolled and received examinations with serum PSA test, digital rectal examination and
transrectal ultrasound. The men with abnormalities in any two of the three examinations were referred to a prostate biopsy.
The men with normal results in any two of the examinations or with a negative biopsy finding were defined as men without
prostate cancer. Men with a prior history of prostate cancer/surgery or with urinary tract infection/obstruction were excluded.
Results A total of 1572 men without prostate cancer were finally included in this study and stratified into 5 age groups, namely
40 to 49, 50 to 59, 60 to 69, 70 to 79, and older than 80 years groups. The median PSA values (95th percentile ranges) of these
age groups were 0.506 (1.565), 1.04 (2.920), 1.16 (4.113), 1.34 (5.561), and 2.975(7.285), respectively, and the 25th to 75th
percentiles were 0.343 to 0.923, 0.663 to 1.580, 0.693 to 2.203, 0.789 to 2.368, and 1.188 to 4.295, respectively. The serum PSA
value was positively correlated with age (r=0.314, P<0.001). Conclusion Using the age-related reference ranges for PSA can
increase the sensitivity for screening prostate cancer in younger men and decrease the biopsy rate in elderly patients.

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更新日期/Last Update: 1900-01-01