[1]刘欣,王节,张舜欣,等.北京地区临床无前列腺癌人群年龄相关性前列腺特异性抗原的参考范围[J].南方医科大学学报,2013,(11):1704.
点击复制

北京地区临床无前列腺癌人群年龄相关性前列腺特异性抗原的参考范围()
分享到：

《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2013年11期
页码:
1704
栏目:
出版日期:
2013-11-15

文章信息/Info

Title:
Age-related reference ranges of serum prostate-specific antigen in men free of prostate cancer in Beijing
作者:
刘欣; 王节; 张舜欣; 林倩
关键词:
年龄; 前列腺癌; 前列腺特异性抗原
Keywords:
age;  prostate cancer;  prostate-specific antigen
摘要:
目的探讨前列腺特异性抗原（PSA）在不同年龄段临床无前列腺癌人群中的参考值范围，以提高PSA在前列腺癌筛查中
的诊断准确性。方法自2010年4月~2011年10月来我院进行正常健康查体的1611例成年男性为参与者。所有参与者均接受
前列腺特异性抗原抽血检查、肛门指检（DRE）及经直肠超声（TRUS）检查。以上三项检查任何两项出现异常者，行前列腺穿刺
活检。最终共有1572位无前列腺癌者纳入本研究。按年龄分为5组，40~49岁、50~59岁、60~69岁、70~79岁、≥80岁。结果中
位数（95%分位数）分别为：40~49岁为0.506（1.565），50~59岁为1.04（2.920），60~69岁为1.16（4.113），70~79岁为1.34（5.561），
80 岁以上为2.975（7.285）。按年龄从低至高各组的25%分位数至75%分位数分别为0.343~0.923，0.663~1.580，0.693~2.203，
0.789~2.368、1.188~4.295。前列腺特异性抗原与年龄呈正相关（r=0.314，P<0.001）。结论在前列腺癌筛查时，对不同年龄段的
人使用不同的血清PSA参考值范围，能提高其诊断准确率，但不同民族和地区应选择适合本地区人群的血清PSA参考值。
Abstract:
Objective To determine the age-related normal ranges of serum prostate-specific antigen (PSA) level in men free of
prostate cancer in Beijing. Methods Form April 2010 to October 2011, 1611 healthy men undergoing routine physical
examinations in our hospital were enrolled and received examinations with serum PSA test, digital rectal examination and
transrectal ultrasound. The men with abnormalities in any two of the three examinations were referred to a prostate biopsy.
The men with normal results in any two of the examinations or with a negative biopsy finding were defined as men without
prostate cancer. Men with a prior history of prostate cancer/surgery or with urinary tract infection/obstruction were excluded.
Results A total of 1572 men without prostate cancer were finally included in this study and stratified into 5 age groups, namely
40 to 49, 50 to 59, 60 to 69, 70 to 79, and older than 80 years groups. The median PSA values (95th percentile ranges) of these
age groups were 0.506 (1.565), 1.04 (2.920), 1.16 (4.113), 1.34 (5.561), and 2.975(7.285), respectively, and the 25th to 75th
percentiles were 0.343 to 0.923, 0.663 to 1.580, 0.693 to 2.203, 0.789 to 2.368, and 1.188 to 4.295, respectively. The serum PSA
value was positively correlated with age (r=0.314, P<0.001). Conclusion Using the age-related reference ranges for PSA can
increase the sensitivity for screening prostate cancer in younger men and decrease the biopsy rate in elderly patients.

相似文献/References:

[1]邓凡 王春霞 许万福 冯丽 柯志勇 Wang Q. Jane 邹志鹏. PKD3上调前列腺癌细胞中PSA表达及机制[J].南方医科大学学报,2010,(08):1779.
　DENG Fan,WANG Chun-xia,XU Wan-fu,et al. PKD3 contributes to up-regulation of prostate-specific antigen in prostate cancer cells[J].,2010,(11):1779.
[2]荆玉明,罗杰,张艳玲,等.p38丝裂原激活蛋白激酶基因重组慢病毒载体的构建及其在建立人前列腺癌稳定细胞株中的应用[J].南方医科大学学报,2012,(03):317.
[3]董金凯,罗津,阎瑾琦,等.小鼠前列腺干细胞抗原的原核表达、纯化及抗原活性检测[J].南方医科大学学报,2012,(04):502.
[4]李炬聪,宋先璐,陆斌,等.晚期糖基化终末产物受体胞外段不同功能段在前列腺癌细胞中的表达与定位[J].南方医科大学学报,2012,(04):507.
[5]王威,高江平,徐阿祥,等.腹膜外途径机器人辅助腹腔镜根治性前列腺切除术：附20例报告[J].南方医科大学学报,2012,(05):749.
[6]周瑞丽,刘国炳.宫颈癌发病年龄与预后的关系(附93例分析)[J].南方医科大学学报,2004,(09):1066.
　ZHOU Rui-li,LIU Guo-bing.Age and prognosis: analysis of their association in 93 cases of cervical cancer[J].,2004,(11):1066.
[7]崔明星,詹新立,刘会江,等.人前列腺癌PC-3细胞的荧光标记及其脊椎转移动物模型的建立[J].南方医科大学学报,2013,(02):243.
[8]邵也常,邓木兰,连子斌,等.广州农村人口基质金属蛋白酶3基因型分布特点及其与血压的关系[J].南方医科大学学报,2013,(04):586.
[9]傅伟,彭辉,陈志强,等.罕见肺腺癌前列腺转移1例报告并文献复习[J].南方医科大学学报,2014,(02):289.
[10]郭东英,彭 辉,冯 媛,等.阻塞性睡眠呼吸暂停低通气综合征与年龄对睡眠结构的影响[J].南方医科大学学报,2015,(06):922.

更新日期/Last Update: 1900-01-01