[1]俞岚,武世伍,周蕾,等.膀胱尿路上皮癌中CD133、CD82/KAI1的表达及其与血管生成拟态的关系[J].南方医科大学学报,2013,(09):1336.
点击复制

膀胱尿路上皮癌中CD133、CD82/KAI1的表达及其与血管生成拟态的关系()
分享到:

《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2013年09期
页码:
1336
栏目:
出版日期:
2013-09-15

文章信息/Info

Title:
Expressions of CD133 and CD82/KAI1 in bladder urothelial carcinoma and their correlation with vasculogenic mimicry
作者:
俞岚武世伍周蕾宋文庆王丹娜
关键词:
膀胱尿路上皮癌CD133CD82/KAI1血管生成拟态免疫组织化学
Keywords:
bladder urothelial carcinoma CD133 CD82/KAI1 vasculogenic mimicry immunohistochemistry
摘要:
目的研究膀胱尿路上皮癌中CD133、CD82/KAI1蛋白与膀胱尿路上皮癌患者各临床病理因素之间的关系。方法采用
免疫组织化学ElivisionTM plus法和特殊组织化学法检测90例膀胱尿路上皮癌和20例正常膀胱粘膜中CD133、CD82/KAI1的表
达和血管生成拟态(VM)的形成情况。结果在正常膀胱粘膜组织中CD133、CD82/KAI1蛋白的表达阳性率和VM检出率分别
为0%、90.0%和0%,在尿路上皮癌组织中三者表达分别为65.6%、31. 1%和31.1%,差异均有显著性(P<0.01)。膀胱尿路上皮癌
中,CD133、CD82/KAI1蛋白阳性表达以及VM的形成与患者的性别、年龄、肿瘤的数量均无相关性(P>0.05);而与肿瘤分化程
度、临床病理分期以及复发与否具有相关性(P<0.01)。癌组织中,CD82/KAI1的表达与VM的形成及CD133的表达成负相关
性(r=-0.452,-0.776,P<0.01-0.05),CD133的表达与VM的形成呈正相关(r=0.487,P<0.05)。结论CD133、CD82/KAI1参与膀
胱尿路上皮癌中VM形成,并且CD133、CD82/KAI1以及VM共同参与尿路上皮癌的侵袭及复发。
Abstract:
Objective To explore the expressions of CD133 and CD82/KAI1 in bladder urothelial carcinoma, their association
with the clinicopathological factors and their roles in vasculogenic mimicry (VM) in the tumor. Methods The expressions of
CD133 and CD82/KAI1 and VM were detected by immunohistochemistry and histochemistry in 90 specimens of bladder
urothelial carcinoma and 20 specimens of normal bladder epithelium tissue. Results The positivity rates of CD133, CD82/KAI1
and VM in normal bladder epithelium tissue were 0, 90% and 0, showing significant differences from the rates of 65.6%, 31.1%
and 31.1% in urothelial carcinoma, respectively (P<0.01). Positive expressions of CD133, CD82/KAI1 and VM were significantly
correlated with pTNM stage and tumor relapse (P<0.01) but not with gender, age, or tumor numbers (P>0.05). CD133
expression was positively correlated with VM (P=0.487, P<0.05), and CD82/KAI1 expression was negatively correlated with
VM (r=-0.452, P<0.01) and CD133 (r=-0.776, P<0.05). Conclusion The expressions of CD133 and CD82/KAI1 proteins are
involved in the occurrence of VM in bladder urothelial carcinoma to contribute to the invasion and relapse of bladder
carcinoma.

相似文献/References:

[1]田平阁,周春平,张超,等.靶向肿瘤干细胞标记CD133特异性结合肽的筛选和初步鉴定[J].南方医科大学学报,2011,(05):761.
[2]钟立业,杜欣,耿素霞,等.CD133 在骨髓增生异常综合征患者中的表达及临床意义[J].南方医科大学学报,2011,(05):854.
[3]陈文晟,马磊,胡晓晔,等.大肠癌细胞中Oct4与CD133的表达及意义[J].南方医科大学学报,2011,(08):1434.
[4]许凯,刘春晓.腹腔镜下扩大淋巴结清扫的根治性膀胱切除术并发症及控瘤效果[J].南方医科大学学报,2012,(07):1012.
[5]兰曦,王勇,曹姝,等.RNA干扰抑制CD133 表达对CD133+肝癌干细胞增殖和化疗敏感性的影响[J].南方医科大学学报,2012,(12):1741.
[6]黎丽旋,张珊珊,梁芬芬,等.无血清培养CD133+Colo205大肠癌细胞可高表达ALDH1[J].南方医科大学学报,2013,(06):889.
[7]李云飞,刘海涛,都兴华,等.EN2与β-catenin在膀胱尿路上皮癌中的表达及其意义[J].南方医科大学学报,2013,(09):1372.
[8]陆国玉,吴晓飞,周蕾,等.CD133和CD44在胃腺癌中的表达及其与E-cadherin的关系[J].南方医科大学学报,2013,(11):1632.
[9]张珊珊,黎丽旋,黄载伟,等.基因芯片技术筛选和鉴定CD133+CD200+大肠癌干细胞相关基因[J].南方医科大学学报,2013,(12):1787.
[10]陈兴月,侯妍利,段丽群,等.131I-CD133mAb联合顺铂在体内外有效抑制人肝癌细胞的生长[J].南方医科大学学报,2014,(07):934.

更新日期/Last Update: 1900-01-01