[1]冯晨,唐锁勤,王建文,等.Topotecan plus cyclophosphamide as maintenance chemotherapy for children with high-risk neuroblastoma in complete remission: short-term curative effects and toxicity[J].南方医科大学学报,2013,(08):1107.
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Topotecan plus cyclophosphamide as maintenance chemotherapy for children with high-risk neuroblastoma in complete remission: short-term curative effects and toxicity()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2013年08期
页码:
1107
栏目:
出版日期:
2013-08-01

文章信息/Info

Title:
拓扑替康联合环磷酰胺的维持化疗方案可安全和有效治疗完全缓解的晚期神经母细胞瘤
作者:
冯晨唐锁勤王建文刘英杨光
关键词:
神经母细胞瘤化疗拓扑替康环磷酰胺
Keywords:
neuroblastoma chemotherapy topotecan cyclophosphamide
摘要:
目的观察拓扑替康与环磷酰胺作为维持化疗方案治疗完全缓解的晚期神经母细胞瘤患儿的相关毒副反应及近期疗效。
方法回顾分析经诱导化疗和手术治疗后完全缓解的16例IV期神经母细胞瘤患儿临床资料,均予3疗程拓扑替康联合环磷酰胺
的维持化疗方案(拓扑替康0.75 mg·m-2·day-1,第0~4天;环磷酰胺:250 mg·m-2·day-1,第0~4天)。应用美国国立癌症研究所通
用不良反应分级标准对化疗相关毒副反应进行评价,观察完全缓解后2年的无病生存率。结果16例患儿化疗相关毒副反应主
要是对骨髓的抑制,粒系100%达到Ⅳ级,红系、巨核系Ⅲ、Ⅳ级毒性损害累积达100%。所有患儿均出现不同程度的感染,经积
极的抗感染治疗均可以控制。消化道、肝脏损害多为Ⅰ、Ⅱ级,经治疗可恢复。未见肾脏、神经、心脏毒副反应病例。该维持化
疗方案2年内无病生存率可达68.75%(11/16)。结论扑替康联合环磷酰胺的维持化疗方案可以安全、有效的治疗Ⅳ期完全缓解
的神经母细胞瘤患儿,是无经济条件应用造血干细胞移植患儿可以选择的维持化疗方案之一。
Abstract:
Objective To evaluate chemotherapy-related toxicity and the short-term efficacy of topotecan and cyclophosphamide
as maintenance chemotherapy for stage IV neuroblastoma in complete remission. Methods The clinical data of 16 children
with stage IV neuroblastoma received 3 cycles of maintenance chemotherapy with topotecan (0.75 mg·m-2·day-1, infused on
days 0-4) and cyclophosphamide 250 mg·m-2·day-1, infused on days 0-4). The two-year event-free survival after complete
remission was recorded and the chemotherapy-related toxicities were evaluated according to the Common Terminology
Criteria for Adverse Events of the National Cancer Institute. Results The most common chemotherapy-related toxicity was
bone marrow suppression and suppressions of neutrophils, hemoglobin and platelets, which occurred in all the patients
mostly of grade III and IV. All the patients experienced episodes of infections, which were controlled effectively with
antibiotics. Impairment of gastrointestinal and liver functions in these cases was mostly mild (grade I and II) and recovered
after corresponding treatments. None of the patients exhibited damages in the nervous system or the renal or cardiac
functions. After complete remission, the two-year event-free survival rate of these patients was 68.75% (11/16). Conclusion
Topotecan plus cyclophosphamide for maintenance chemotherapy can be effective and relative safe for stage IV
neuroblastoma in complete remission, thus giving a chance to those patients who choose not to have stem cell transplantation.

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更新日期/Last Update: 1900-01-01