[1]史琳,张安文,罗宇,等.细胞周期正性调控因子的异常表达与甲状腺癌发生发展的关系[J].南方医科大学学报,2013,(07):1031.
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细胞周期正性调控因子的异常表达与甲状腺癌发生发展的关系()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2013年07期
页码:
1031
栏目:
出版日期:
2013-07-15

文章信息/Info

Title:
Abnormal expressions of positive cell cycle control factors and thyroid carcinoma occurrence and progression
作者:
史琳张安文罗宇赵时梅田海妍杨燕初
关键词:
甲状腺癌MCM7CDK2Ki-67免疫组织化学
Keywords:
thyroid carcinoma MCM7 CDK2 Ki-67 immunohistochemistry
摘要:
目的探讨细胞周期正性调控因子的异常表达与人甲状腺癌发生、发展的关系,并评价其在判断甲状腺肿瘤细胞增殖
活性和病人预后方面的应用价值。方法采用免疫组织化学SP法检测50 例甲状腺癌、30 例甲状腺腺瘤、30 例结节性甲状腺
肿及20 例正常甲状腺组织中MCM7、CDK2 及Ki-67 蛋白的表达。结果癌组中MCM7、CDK2 及Ki-67 蛋白的阳性表达率均
显著高于在腺瘤组、结甲组及正常组中的表达(均为P<0.01),分别为100.00%(50/50)、80.00%(40/50)、84.00%(42/50)。癌组中
三者的蛋白表达两两比较,均呈正相关(均为P<0.01)。结论甲状腺癌中MCM7、CDK2 及Ki-67 蛋白的高表达可能与癌的
发生相关,三者联合应用或许可作为临床早期诊断和评价预后的生物学指标。在评价甲状腺肿瘤细胞增殖活性方面,MCM7优
于Ki-67。
Abstract:
Objective To explore the relationship between abnormal expressions of positive cell cycle control factors and thyroid
carcinoma occurrence and progression, and assess the value of these factors in evaluating tumor cell proliferation activity and
the prognosis of the patients. Methods Immunohistochemical SP method was used to detect the expressions of MCM7, CDK2
and Ki-67 proteins in 50 cases of thyroid carcinoma, 30 cases of thyroid adenoma, 30 cases of nodular goiter and 20 cases of
normal thyroid gland tissues. Results The positive rates of MCM7, CDK2 and Ki-67 expressions in thyroid carcinoma were
100% (50/50), 80.00% (40/50) and 84.00% (42/50), significantly higher than the rates in thyroid adenoma, nodular goiter and
normal thyroid tissue (P<0.01). In thyroid carcinoma tissues, positive correlations were observed between the expressions of
MCM7 and CDK2 proteins (r=0.637, P<0.01), MCM7 and Ki-67 proteins (r=0.633, P<0.01), and CDK2 and Ki-67 proteins (r=
0.862, P<0.01). Conclusion The high expressions of MCM7, CDK2 and Ki-67 protein may contribute to the development of
thyroid carcinoma, and their combined examination may serve as useful index for early diagnosis and prognostic evaluation of
thyroid carcinoma. MCM7 is superior to Ki-67 in the evaluation of the thyroid tumor cell proliferation activity.

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[2]邵礼成,菅洪健,陈广辉,等.中青年分化型甲状腺癌患者术后复发与生存分析[J].南方医科大学学报,2017,(02):274.
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更新日期/Last Update: 1900-01-01