[1]张月,周颖,刘真,等.CDK4蛋白在胞浆中的表达与肺癌临床病理学特征及预后的关系[J].南方医科大学学报,2012,(11):1572.
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CDK4蛋白在胞浆中的表达与肺癌临床病理学特征及预后的关系()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2012年11期
页码:
1572
栏目:
出版日期:
2012-11-15

文章信息/Info

Title:
Cytoplasmicexpression of CDK4protein and its correlation with the clinicopathologic features and prognosis of lung cancer
作者:
张月周颖刘真方唯意
关键词:
CDK4蛋白肺癌胞浆过表达预后因子
Keywords:
CDK4protein lung cancer cytoplasmic overexpression prognostic factor
摘要:
目的评估CDK4蛋白在胞浆中表达与肺癌患者临床病理学特征的关系。方法利用免疫组化和统计学方法分析CDK4
蛋白在胞浆中表达以及与肺癌患者临床病理参数及预后之间的相关性。结果与正常肺组织相比,CDK4蛋白在肺癌胞浆中的
表达并没有明显增高(P=1.000)。然而,在肺癌组织中,CDK4表达上调正向相关于患者的临床分期和淋巴结转移(P=0.001,P=
0.001)。预后分析表明,CDK4蛋白在胞浆表达越高,患者生存时间越短。多变量分析显示,CDK4在胞浆中过表达是预测肺癌
患者预后不利因素(P<0.001)。结论CDK4蛋白在细胞胞浆中过表达也促进肺癌的发病过程,且其是预测肺癌患者预后的不利
因子。
Abstract:
ObjectiveTo evaluate the correlation of CDK4protein expression in the cytoplasm with the clinicopathologic
features and prognosis of lung cancer.MethodsImmunohistochemistry was employed to examine CDK4protein expression in
the cytoplasm of lung cancer samples, using normal lung tissue samples as control. The correlation of cytoplasmic CDK4
protein expression with the clinicopathologic parameters and prognosis of lung cancer patients was analyzed.ResultsNo
significant difference was found in cytoplasmic CDK4protein expression levels between lung cancer and normal lung tissues
(P=1.000). In the lung cancer tissues, however, an increased cytoplasmic expression of CDK4was positively correlated with the
clinical stages and lymph node metastasis. Prognostic analysis showed that the patients with an increased cytoplasmic CDK4
expression had a markedly shorter overall survival than those with a low cytoplasmic CDK4expression. Multivariate analysis
suggested that the level of cytoplasmic CDK4expression was an independent prognostic indicator for the survival of patients
with lung cancer (P<0.001).ConclusionOverexpression of CDK4protein in the cytoplasm may promote the carcinogenesis of
lung cancer and can be an unfavorable prognostic factor for the survival of lung cancer patients.

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更新日期/Last Update: 1900-01-01