[1]刘占国,谭晓莹,蔡靓,等.脓毒症患者血清IL-6与脑损伤的相关性分析[J].南方医科大学学报,2012,(10):1451.
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脓毒症患者血清IL-6与脑损伤的相关性分析()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2012年10期
页码:
1451
栏目:
出版日期:
2012-10-01

文章信息/Info

Title:
Correlation analysis between serum interleukin-6and central nervous injury in septic patients
作者:
刘占国谭晓莹蔡靓杨祥锐常平
关键词:
脓毒症脑损伤IL-6神经元特异性烯醇化酶
Keywords:
sepsis brain injury interleukin-6 neuron-specific enolase
摘要:
目的探讨脓毒症患者血清白细胞介素-6(IL -6)水平与中枢神经损伤的关系。方法选择符合脓毒症诊断标准同时无中枢
神经系统疾病的患者22例作为研究对象,检测血清IL-6和神经元特异性烯醇化酶(NSE)水平,并根据IL-6的水平分为低中高3
个浓度组,比较3个浓度组NSE水平及急性生理和慢性健康(APACHEII)评分的差异,分析血清IL-6与NSE及APACHEII的
相关性。结果IL-6低中高3个浓度组NSE水平具有显著性差异(P<0.001),浓度分别为(10.29±4.05)、(16.06±5.84)、(23.97±
3.28)μg/L。IL-6三个浓度组的APACHEII评分同样具有显著性差异(P=0.009),分值分别为14.17±4.67、16.40±4.84和24.00±
6.26。相关性分析显示IL-6与NSE和APACHEII评分均具有显著的正相关性,相关系数分别为r=0.788(P<0.001)和0.733(P<
0.001)。结论脓毒症患者血清IL-6的浓度同患者危重程度和中枢神经损伤均有显著地相关性,可以作为动态监测脓毒性脑损
伤的标志物。
Abstract:
ObjectiveTo explore the relationship between interleukin-6(IL-6) production and central nervous injury in septic
patients.MethodsTwenty-two septic patients without central nervous system diseases were examined for serum IL-6and
neuron-specific enolase (NSE) levels, and the serum NSE levels and APACHEII scores were compared between patients with
low, moderate, and high serum IL-6levels. The correlations between NSE, APACHEII and serum IL-6were analyzed.Results
In patients with low, moderate, and high serum IL-6levels, the serum levels of NSE were10.29±4.05, 16.06±5.84and23.97±3.28
μg/L, respectively, showinga significant difference betweenthe 3 groups (P<0.001). The APACHEII scores also differed
significantly between the3groups (14.17±4.67, 16.40±4.84, and 24.00±6.26, respectively, P=0.009). Correlation analysis showed
significant positive correlations of IL-6with NSE (r=0.788, P<0.001) and with APACHEII scores (r=0.733, P<0.001).Conclusion
In septic patients, serum IL-6level is significantly correlated with the severity of sepsis and brain injury, and can be used as a
marker to monitor brain injury in septic patients.

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更新日期/Last Update: 1900-01-01