[1]张琳.支原体肺炎发病机制及临床分析[J].南方医科大学学报,2005,(12):1574-1576.
　ZHANG Lin.Clinical analysis of the pathogenesis of mycoplasma pneumonia in children[J].Journal of Southern Medical University,2005,(12):1574-1576.
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支原体肺炎发病机制及临床分析()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2005年12期
页码:
1574-1576
栏目:
出版日期:
2005-12-01

文章信息/Info

Title:
Clinical analysis of the pathogenesis of mycoplasma pneumonia in children
作者:
张琳
解放军309医院呼吸科, 北京, 100071
Author(s):
ZHANG Lin
Department of Respiratory Diseases, 309 Hospital of PLA, 100071 Beijing, China
关键词:
支原体肺炎; 发病机制; 免疫复合物; 肺炎支原体
Keywords:
mycoplasma pneumoniae; pathogenesis; immune complex
分类号:
R563.1
摘要:
目的 探讨支原体肺炎免疫发病机制及其临床特点。方法 对485例有呼吸道感染的患儿进行血清抗肺炎支原体(mycoplasmapneumoniae,MP)IgM和咽拭子MPDNAPCR检测,同时对45例肺炎患儿进行血清IgG、IgM、总补体活性(CH50)和循环免疫复合物(CIC)测定。结果 MPDNAPCR检测结果与血清MP抗IgM结果有显著性差异(P<0.05);MP肺炎组CIC阳性率为44%(11/25);非MP肺炎组阳性率为10%(2/20),前者明显高于后者,差异有显著性(P<0.01);MP肺炎组血清IgG、IgM浓度高于非MP肺炎组,两组差异显著(P<0.05);而CH50则明显低于对照组(P<0.05)。结论 MPDNAPCR检测有利于早期诊断治疗;免疫复合物介导损伤可能与MP肺炎的发病有关。
Abstract:
Objective To study the clinical features and immune-mediated pathogenesis of mycoplasma pneumonia (MP) in children. Methods The DNA of mycoplasma in nasopharyngeal swabs was detected by PCR in 485 children with respiratory tract infection, and serum circulating immune complex (CIC), IgG, IgM, MP IgM, and CH50 were measured on the same day in 45 children with pneumonia. Results Significant difference was noted between the results of mycoplasma DNA PCR detection and those of serum IgM detection. The positivity rate of CIC was 44% in children with MP whereas that in the control group was only 10% (P<0.01). The levels of serum IgG and IgM in MP group was significantly higher and serum CH50 lower than those of the control group (P<0.05). Conclusion Mycoplasma DNA detection facilitates early diagnosis and treatment of MP, whose pathogenesis in children may be involved in immune-mediated mechanism.

参考文献/References:

[1] 胡亚美,江载芳.诸福棠实用儿科学[M].第7版,北京:人民卫生出版社,2002.1204-5.
[2] 杨莉,李海浪.小儿肺炎支原体感染诊断及发病机制探讨[J].铁道医学,1998,26(2):78-80.Yang L,Li HL.The discussion of diagnosis and mechanism of mycoplasma pneumonia in children[J].J Railway Med,1998,26(2):78-80.
[3] 史端明,雷春莲.肺炎支原体感染免疫研究进展[J].国外医学·妇幼保健分册,2002,13(2):94-6.
[4] Michelow IC,Olsen K,Lozano J,et al.Diagnostic utility and clinical significance of naso-and oropharyngeal samples used in a PCR assay to diagnose Mycoplasma pneumoniae infection in children with community-acquired pneumonia[J].J Clin Microbiol,2004,42(7):3339-41.
[5] Dorigo-Zetsma JW,Wilbrink B,Van der Nat H,et al.Results of molecular detection of Mycoplasma pneumoniae among patients with acute respiratory infection and in their household contacts reveals children as human reservoir [J].J Infect Dis,2001,183 (4):675-8.
[6] Drummond P,Clark J,Wheeler J,et al.Community acquired pneumonia-a prospective UK study[J].Arch Dis Child,2000,83(5):405-12.
[7] 张宁.肺炎支原体感染诱发咳嗽变异性哮喘20例[J].实用儿科临床杂志,2003,18(10):787-8.
[8] 唐立萍,葛青玮,蒋巍.呼吸道感染患儿1379例肺炎支原体IgM抗体的检测[J].上海医学检验杂志,2001,16(4):249-50.

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备注/Memo

备注/Memo:
收稿日期:2004-12-5。
作者简介:张琳,女,2002年毕业于南方医科大学,硕士,主治医师.
更新日期/Last Update: 1900-01-01