[1]陈明玉,周再高,曾抗,等.伴有血小板减少的系统性红斑狼疮34例分析[J].南方医科大学学报,2005,(10):1280-1282.
 CHEN Ming-yu,ZHOU Zai-gao,ZENG Kang,et al.Analysis of 34 cases of systemic lupus erythematosus with decreased platelet count[J].,2005,(10):1280-1282.
点击复制

伴有血小板减少的系统性红斑狼疮34例分析()
分享到:

《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2005年10期
页码:
1280-1282
栏目:
出版日期:
2005-10-01

文章信息/Info

Title:
Analysis of 34 cases of systemic lupus erythematosus with decreased platelet count
作者:
陈明玉1 周再高1 曾抗1 孙乐栋1 丁立峰2
1. 南方医科大学南方医院皮肤风湿科, 广东, 广州, 510515;
2. 南城县人民医院麻醉科, 江西, 南城, 344700
Author(s):
CHEN Ming-yu1 ZHOU Zai-gao1 ZENG Kang1 SUN Le-dong1 DING Li-feng2
1. Department of Dermatology and Rheumatology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China;
2. Department of Anesthesiology, People’s Hospital of Nancheng, Nancheng 344700, China
关键词:
系统性红斑狼疮血小板血小板比容血小板分别宽度
Keywords:
systemic lupus erythematosusplateletthrombocytocritplatelet distribution width
分类号:
R593.241
摘要:
目的 了解伴有血小板减少的系统性红斑狼疮临床及实验室检查特征。方法 对34例伴有血小板减少的系统性红斑狼疮与随机抽取的40例血小板正常系统性红斑狼疮患者的临床特点进行对照研究,分析其首发症状、临床表现及实验室检查改变。结果 血小板减少组肾脏损害的发生率高于血小板正常患者,但蝶形红斑的发生率低于后者,均有统计学意义(P<0.05),实验室指标,CH50、白细胞下降程度和尿蛋白出现率明显高于血小板正常组,而血小板比容、血小板分布宽度出现异常高于血小板正常组。结论 伴有血小板减少的系统性红斑狼疮患者临床及实验室检查与血小板正常患者比某些程度存在差异。
Abstract:
Objective To explore the clinical and laboratory examination features of systemic lupus erythematosus (SLE) with decreased platelet count. Methods Thirty-four SLE patients with decreased platelet count were analyzed for their initial symptoms, clinical manifestations, involvement of the organs and laboratory findings in comparison with 40 randomly selected SLE patients with normal platelet count. Results The SLE patients with decreased platelet count were more likely to develop kidney involvement than those with normal platelet, but the incidence of butterfly erythema was significantly lower in the former patients (P<0.05). Some indices of laboratory examinations, such as CH50, white blood cell reduction, rate of urine protein, thrombocytocrit and platelet distribution width were significantly higher in SLE patients with decreased platelet count than those with normal platelet count. Conclusion The clinical manifestations and laboratory findings in SLE patients with decreased platelet count may differ from those of SLE patients with normal platelet.

参考文献/References:

[1] Tolusso B, Fabris M, Gremese E, et al. Platelet GPⅡb/Ⅲa(PIA 1/2)polymorphism in SLE: clinical and laboratory association [J]. Ann Rheum Dis, 2003, 62(8): 781-2.
[2] 苏尚焙.系统性红斑狼疮474例临床分析[J].临床皮肤科杂志,1996,25(2):80-1.SuSP. Clinical analysis of 34 case of systemic lupus erythematosus [J]. J Clin Dermatol, 1996, 25(2): 80-1.
[3] 林文杰,陈韧,许敬才,等.15例系统性红斑狼疮长期误诊为特发性血小板减少性紫癜的临床分析[J].实用医学杂志,1997,13(9):629.
[4] 赵辨.临床皮肤性病学[M].第3版,南京:江苏科学技术出版社,2001.661.
[5] 秦秀娟,郭岿.补体与血沉在系统性红斑狼疮病情转归中的意义[J].现代中西医结合杂志,2001,10(4):352.
[6] 毛达勇,崔礼敬,闫文强,等.血小板四参数正常参考范围的研究[J].郧阳医学院学报,1996,15(2):84.Mao DY, Cui LJ, Yan WQ, et al. The study of four parameters reference value of PLT[J]. J Yunyang Med Coll, 1996, 15(2): 84.
[7] Koltai M, Hosford D, Guinot P, et al. Platelet activating factor (PAF).A review of its efects, antagonists possible future clinical applications (Part Ⅰ)[J]. Drugs, 1991, 42(1): 9-29.
[8] Ruiz-Ortega M, Bustos C, Plaza J J, et al. Overexpression of extracellular matrix proteins in renal tubulointerstitial cells by plateletactivating-factor stimulation[J]. Nephrol Dial Transplant, 1998, 13(4): 886-92.
[9] 陈慰峰.医学免疫学[M].第4版,北京:人民卫生出版社,2004.202.

相似文献/References:

[1]李毓阳,戴永江,邓斌,等.复方甘草酸苷对系统性红斑狼疮患者CD4+CD25+T细胞的表达及损伤指数的影响[J].南方医科大学学报,2011,(07):1285.
[2]罗微,马骊,姚新生,等.系统性红斑狼疮患者外周血T细胞TCRβ链CDR3谱系漂移和序列鉴定[J].南方医科大学学报,2006,(08):1128.
 LUO Wei,MA Li,YAO Xin-sheng,et al.Complementarity-determining region 3 analysis of T cell receptor beta chain variable region in peripheral blood mononuclear cells of patients with systemic lupus erythematosus[J].,2006,(10):1128.
[3]吴元胜,范瑞强,陈达灿,等.基因芯片技术分析系统性红斑狼疮患者外周血白细胞基因表达谱的初步研究[J].南方医科大学学报,2005,(08):929.
 WU Yuan-sheng,FAN Rui-qiang,CHEN Da-can,et al.Gene expression profiling of peripheral leukocytes from patients with systemic lupus erythema- tosus using oligonucleotide DNA microarray[J].,2005,(10):929.
[4]周志刚,朱美华,梁中锟,等.系统性红斑狼疮儿童特异性全长抗体基因库的构建与分析[J].南方医科大学学报,2012,(08):1082.
[5]李广华,罗燕飞,罗盈,等.流式细胞术检测VASP的磷酸化程度可监测氯吡格雷抵抗[J].南方医科大学学报,2014,(03):434.
[6]章俊,马亚琼,邱敏姿,等.中国汉族TMEM39A基因单核苷酸多态性与系统性红斑狼疮的相关性[J].南方医科大学学报,2014,(04):556.
[7]彭宇声,黎 倩,王梦蕾,等.碱性亮氨酸拉链转录因子ATF样蛋白在狼疮小鼠肾脏组织中的表达及意义[J].南方医科大学学报,2015,(06):816.
[8]付绍杰,郭彬彬,于立新,等.血小板与肾移植术后早期移植肾功能延迟性恢复的关系[J].南方医科大学学报,2014,(07):994.
[9]张建杏,李红英,周国斌,等.止血带性肢体缺血再灌注损伤后血小板线粒体的变化[J].南方医科大学学报,2014,(07):1075.
[10]付绍杰,梁永杰,于立新,等.血小板参数与肾移植术后急性排斥反应的关系[J].南方医科大学学报,2015,(03):413.

备注/Memo

备注/Memo:
收稿日期:2005-4-19。
作者简介:陈明玉(1975- ),男,在读硕士研究生,电话020-61641984,E-mail:chenmingyu3w@163.com
更新日期/Last Update: 1900-01-01