[1]詹瑛,陈维萍,叶元华,等.妊娠高血压患者胎盘组织基质金属蛋白酶-9与肿瘤坏死因子-α的表达[J].南方医科大学学报,2005,(08):1070-1071,1074.
 ZHAN Ying,CHEN Wei-ping,YE Yuan-hua,et al.Expression of matrix metalloproteinase-9 and tumor necrosis factor-α in the placenta of patients with pregnancy-induced hypertension[J].,2005,(08):1070-1071,1074.
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妊娠高血压患者胎盘组织基质金属蛋白酶-9与肿瘤坏死因子-α的表达
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2005年08期
页码:
1070-1071,1074
栏目:
出版日期:
2005-08-01

文章信息/Info

Title:
Expression of matrix metalloproteinase-9 and tumor necrosis factor-α in the placenta of patients with pregnancy-induced hypertension
作者:
詹瑛 陈维萍 叶元华 楼艳辉
青岛大学医学院附属医院, 山东, 青岛, 266003
Author(s):
ZHAN Ying CHEN Wei-ping YE Yuan-hua LOU Yan-hui
Department of Obstetrics, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China
关键词:
妊娠并发症心血管高血压基质金属蛋白酶肿瘤坏死因子
Keywords:
pegnancy complications cardiovascularhypertensionmatrix metalloproteinasetumor necrosis factors
分类号:
R714
摘要:
目的 探讨基质金属蛋白酶-9(MMP-9)、肿瘤坏死因子-α(TNF-α)在妊娠期高血压疾病(简称妊高征)发病机制中的作用。方法 采用免疫组化法检测57例妊高征患者和24例正常妊娠产妇胎盘绒毛上皮组织中MMP-9、TNF-α的表达。结果 轻度妊高征组MMP-9的阳性表达与对照组相比,差异无显著性(P>0.05),而中、重度妊高征组阳性表达明显弱于正常妊娠组(P<0.01),且中、重度妊高征组间比较差异也有显著性(P<0.05)。对照组与轻、中、重度妊高征患者胎盘组织TNF-α表达水平比较,差异有显著性,(分别为P<0.05、P<0.01、P<0.01),且妊高征组中不同程度组间比较,差异也有极显著性(P<0.01)。对照组和轻度妊高征组,MMP-9与TNF-α表达无相关性(r=0.287、P>0.05及r=0.382、P>0.05),但中、重度妊高征患者,MMP-9与TNF-α表达水平存在显著的负相关性(r=-0.563、P<0.05及r=-0.681、P<0.01)。结论 妊高征患者MMP-9表达下降,胎盘不完全侵入,胎盘局部缺血、缺氧,TNF-α表达增多,可能是引发妊高征的原因之一。
Abstract:
Objective To investigate the role of matrix metalloproteinase-9 (MMP-9) and tumor necrosis factor-α (TNF-α) in the pathogenesis of pregnancy-induced hypertension (PIH). Methods The placenta samples were collected from 57 patients with PIH and 24 normal pregnant women. Immunohisochemical staining was used to examine positive expression of MMP-9 and TNF-α in these samples. Results The positive expression of MMP-9 in the normal group was significantly higher than that in patients with moderate or severe PIH (P<0.01), while no significant difference was found between normal pregnant women and patients with mild PIH (P>0.05), and expression decreased drastically with the progression of PIH (P<0.05). The expression of TNF-α in the patients with mild, moderate and severe PIH groups were significantly higher than that in the normal group (P<0.05, P<0.01 and P<0.01, respectively), and the differences were also significant between the PIH groups of different severities (P<0.01). No correlation was found between MMP-9 and TNF-α expressions in the normal and mild PIH groups (r=0.287, P>0.05; r=0.382, P>0.05), in the patients with moderate and severe PIH, MMP-9 expression showed inverse correlation with TNF-α expression (r=-0.563, P<0.05; r=-0.681, P<0.01). Conclusion Loweed MMP-9 expression in syncytio- trophoblast might result in defective nidation in the placenta where local ischemia and hypoxia cause abnormal TNF-α elevation, which might be one of the important factors inducing PIH.

参考文献/References:

[1] Wang H, Li Q, Shao L, et al. Expression ofmetalloproteinases-2,-9,-14,and tissue inhibitor of metalloproteinases-1,-2,-3 in the endometrium and placenta ofrhesus monkey (macaca mulatta)during early pregnancy[J]. Biol Reprod, 2001, 65(1): 31-40.
[2] Argiles JM, Carbo N, Lopez-Soriano FJ. TNF and pregnancy:the paradigm of a complex interaction[J]. Cytokine Growth Factor Rev,1997, 8: 181-8.
[3] BischofP, Meisser A, Campana A. Control of MMP-9 expression at the maternal-fetal interface[J]. J Reprod Immunol, 2002, 55 (1-2):3-10.
[4] Lyall F, Simpson H, Nicola BJ, et al. Transforming growth factorbate expression in human placenta and placental bed in third trimester normal pregnancy, preeclampsia, and fetal growth restriction[J]. Am J Pathol, 2001, 159(5): 1827-38.
[5] Ishihara N, Matsuo H, Murakoshi H, et al. Increased apoptosis in the syncytiotrophoblast in human term placentas complicated by either preeclampsia or intrauterine growth retardation[J]. Am J Obstet Gynecol, 2000, 186(1): 158-66.
[6] Xu P, Wang YL, Piao YS, et al. Effects of matrix proteins on the expression of matrix metalloproteinase-2,-9,and -14 and tissue inhitions of metalloproteinases in human cytotrophoblast cells during the first trimester[J]. Biol Reprod, 2001, 65(1): 240-6.

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备注/Memo

备注/Memo:
收稿日期:2005-5-8。
作者简介:詹瑛(1965-),女,1996年毕业于第二军医大学,硕士学位,副主任医师,电话:0532-82911321,E-mail:nnns6@yahoo.com.cn
更新日期/Last Update: 1900-01-01