[1]方咏红,张继平,周少雄,等.2型糖尿病患者血清血管性血友病因子、血小板活化因子水平与糖尿病肾病的关系[J].南方医科大学学报,2005,(06):729-731.
 FANG Yong-hong,ZHANG Ji-Ping,ZHOU Shao-xiong,et al.Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy[J].Journal of Southern Medical University,2005,(06):729-731.
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2型糖尿病患者血清血管性血友病因子、血小板活化因子水平与糖尿病肾病的关系()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2005年06期
页码:
729-731
栏目:
出版日期:
2005-06-01

文章信息/Info

Title:
Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy
作者:
方咏红 张继平 周少雄 郑菊芬 余永卫 晏世刚 范文奎 陈月崧
佛山市第三人民医院, 广东, 佛山, 528000
Author(s):
FANG Yong-hong ZHANG Ji-Ping ZHOU Shao-xiong ZHENG Ju-fen YU Yong-wei YAN Shi-gang FAN Wen-kui CHENG Yue-song
Second People’s Hospital of Foshan City, Foshan 528000, China
关键词:
2型糖尿病糖尿病肾病血管性血友病因子血小板活化因子
Keywords:
type 2 diabetesdiabetic nephropathyvon Willebrand factorplatelet-activating factor
分类号:
R587.1
摘要:
目的 探讨2型糖尿病患者尿微量白蛋白(UALB)、血管性血友病因子(vWF)、血小板活化因子(PAF)变化及临床意义。方法 研究对象分5组:糖尿病肾病患者(A组),2型糖尿病无肾病并发症患者(B组)、糖耐量受损者(C组)、糖耐量正常的2型糖尿病患者一级亲属(D组)、无2型糖尿病家族史糖耐量正常受试者(E组),每组30例,分别检测UALB、vWF、PAF水平,并进行统计分析。结果 A组UALB、PAF含量明显高于其他4组(P<0.01),其他4组间UALB、PAF差异无显著性(P>0.05);A组vWF含量与B、C、D组比较差异有显著性(P<0.05)。结论 2型糖尿病微血管并发症患者存在肾功能损害和血小板活化,两者变化同步,提示其血管损伤与PAF含量升高有关。
Abstract:
Objective To observe the changes in urine albumin (UALB), von Willebrand factor (vWF) and platelet-activating factor (PAF) in different courses of type 2 diabetes. Methods Levels of UALB, vWF and PAF were determined in 30 type 2 diabetic nephropathy patients(group A), type 2 diabetic patients without DNP(group B, n=30), patients with impaired glucose tolerance (group C, n=30), the first-degree relatives of type 2 diabetic patients with normal glucose tolerance(group D, n=30) and 30 normal glucose tolerance subjects without family history of type 2 diabetes(group E). Results UALB and PAF contents were significantly higher in group A than in the other groups (P<0.01), while between the latter 4 groups, the contents showed no significant differences (P>0.05). Serum vWF level was significantly higher in group A than those in the other groups (P<0.05). Conclusion Renal dysfunction and platelet activation are present in type 2 diabetes with microvascular complications, and the synchronized changes between renal dysfunction and platelet activation indicate the involvement of elevated PAF in vascular injury.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2004-12-28。
基金项目:广东省自然科学基金(2004B36001009);佛山市科技发展专项基金(0108007A)
作者简介:方咏红(1960- ),女,副主任医师
更新日期/Last Update: 1900-01-01