[1]蔡珠华,何援利,彭冬先.子宫内膜异位症患者血清中ENA-78的表达[J].南方医科大学学报,2005,(04):464-465.
 CAI Zhu-hua,HE Yuan-li,PENG Dong-xian.Changes of serum epithelial neutrophil-activating peptide-78 in patients with endometriosis[J].,2005,(04):464-465.
点击复制

子宫内膜异位症患者血清中ENA-78的表达()
分享到:

《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2005年04期
页码:
464-465
栏目:
出版日期:
2005-04-01

文章信息/Info

Title:
Changes of serum epithelial neutrophil-activating peptide-78 in patients with endometriosis
作者:
蔡珠华 何援利 彭冬先
南方医科大学珠江医院妇产科, 广东, 广州, 510282
Author(s):
CAI Zhu-hua HE Yuan-li PENG Dong-xian
Department of Obstetrics and Gynecology, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China
关键词:
子宫内膜异位症ENA-78酶联免疫吸附实验
Keywords:
endometriosisepithelial neutrophil-activing peptide-78ELISA
分类号:
R446.6;R711.22
摘要:
目的 研究上皮细胞来源的中性粒细胞激活肽(ENA-78)在子宫内膜异位症发病中的作用。方法 应用ELISA法,检测42例子宫内膜异位症患者(Ⅰ~Ⅱ期20例、Ⅲ~Ⅳ期22例)血清ENA-78的浓度,并与25例非子宫内膜异位症患者(对照组)进行比较。结果 子宫内膜异位症组血清中ENA-78浓度明显高于对照组(2.97±1.91ng/ml vs 0.72±0.24ng/ml,P<0.001),Ⅲ、Ⅳ期比Ⅰ、Ⅱ患者血清中ENA-78增高更明显(4.48±1.25ng/mlvs1.30±0.74ng/ml,P<0.001)。增殖期与分泌期比较,两组血清ENA-78的表达均无显著差异。结论 子宫内膜异位症患者ENA-78明显升高,可能为子宫内膜异位症发病的因素之一。
Abstract:
Objective To investigate the role of serum epithelial neutrophil-activating peptide-78 (ENA-78) in the pathogenesis of endometriosis. Methods Serum concentrations of ENA-78 were measured by means of enzyme-linked immunosobent assay (ELISA) in 42 patients with endometriosis (20 in stages Ⅰand Ⅱ and 22 in stages Ⅲ and Ⅳ) in comparison with 25 women without endometriosis (control group). Results Serum concentrations of ENA-78 were significantly higher in endometriosis group than in the control group (2.97±1.91 ng/ml vs 0.72±0.24 ng/ml, P<0.001), and ENA-78 levels in stages Ⅲ and Ⅳ were significantly higher than those in stagesⅠ and Ⅱ (4.48±1.25 ng/ml vs 1.30±0.74 ng/ml, P<0.001). Significant difference in ENA-78 levels between follicular phase and luteal phase was found in neither of the groups. Conclusion Patients with endometriosis have elevated serum ENA-78 levels, which might be a pathogenic factor of endometriosis.

参考文献/References:

[1] Lebovic DL, Mueller MD, Taylor RN. Immunobiology of endometriosis[J]. Fertil Steril, 2001, 75(1): 1-10.
[2] Nasu K, Arima K, Kai K, et al. Expression of epithelial neutrophilactivating peptide-78 in culcture human endometrial stromal cells[J]. Mol Hum Reprod, 2001, 7(5): 453-8.
[3] 刘木彪,何援利,彭冬先.子宫内膜异位症患者腹腔液血管内皮生长因子与内异素的表达[J].第一军医大学学报,2004,24(1):69-71.Liu MB, He YL, Peng DX. Expression of vascular endothelial growth factor and endostatin in peritoneal fluid of patients with endometriosis[J]. J First Mil Med Univ/Di Yi Jun Yi Da Xue Xue Bao, 2004, 24(1): 69-71.
[4] Suzumori N, Katano K, Suzumori K. Peritoneal fluid concentrations of epithelial neutrophil-activating peptide-78 correlate with the severity of endometriosis[J]. Fertil Steril, 2004, 81 (2): 305-8.
[5] Addison CL, Daniel TO, Burdick MD, et al. The CXC chemokine receptor 2, CXCR2, is the putative receptor for ELR+ CXC chemokine-induced angiogenic activity[J]. J Immunol, 2000, 165(9): 5269-77.
[6] Koch AE, Yolin MV, Woods JM, et al. Regulation of angiogenesis by the C-X-C chenokines interleukin-8 and epithelial neutrophilactivating peptide-78 in the rheumatoid joint[J]. Arthritis Rheum,2001, 44(1): 31-40.
[7] 宗利丽,李亚里,汪龙霞,等.子宫内膜异位症猕猴动物模型的建立[J].第一军医大学学报,2003,23(10):1006-9.Zong LL, Li YL, Wang LX, et al. Establishment of animal models of endometriosis in rhesus monkeys[J]. J First Mil Med Univ/Di Yi Jun Yi Da Xue Xue Bao, 2003, 23(10): 1006-9.

相似文献/References:

[1]易华,卢月,陈剑坤,等. 青藤碱对子宫内膜异位症大鼠异位组织TNF-琢和NF-资B 水平的影响[J].南方医科大学学报,2010,(08):1874.
 YI Hua,LU Yue,CHEN Jian-kun,et al.Effect of sinomenine on tumor necrosis factor-琢and nuclear factor-资B in the heterotopictissue in rats with endometriosis[J].,2010,(04):1874.
[2]李洁,汪淑娟,孙璐,等.抑癌基因ARHI 在子宫内膜异位症及非子宫内膜异位症患者中差异表达的意义[J].南方医科大学学报,2011,(05):796.
[3]罗敏,何援利,张宏斌,等.广东妇女子宫内膜异位症与肿瘤坏死因子-β基因多态性的相关性研究[J].南方医科大学学报,2006,(08):1163.
 LUO Min,HE Yuan-li,ZHANG Hong-bin,et al.Association of tumor necrosis factors-β gene polymorphism with endometriosis in women in Guangdong Province[J].,2006,(04):1163.
[4]宗利丽,李亚里,宋三泰,等.子宫内膜异位症患者肝细胞生长因子及其受体c-Met的表达[J].南方医科大学学报,2004,(06):619.
 ZONG Li-li,LI Ya-li,SONG San-tai,et al.Expression of hepatocyte growth factor and its receptor c-met gene in the endometrium of women with endometriosis[J].,2004,(04):619.
[5]赵军,宗利丽,李亚里.整合素avβ3单克隆抗体对小鼠子宫内膜异位病灶的抑制作用[J].南方医科大学学报,2005,(06):709.
 ZHAO Jun,ZONG Li-li,LI Ya-li.Inhibitory effects of integrin avβ3 monoclonal antibody on implanted lesions of endometriosis model of SCID mouse[J].,2005,(04):709.
[6]刘木彪,何援利,彭冬先.子宫内膜异位症患者腹腔液血管内皮生长因子与内抑素的表达[J].南方医科大学学报,2004,(01):69.
 LIU Mu-biao,HE Yuan-li,PENG Dong-xian.Expression of vascular endothelial growth factor and endostatin in peritoneal fluid of patients with endometriosis[J].,2004,(04):69.
[7]王芳,何援利,彭冬先,等.子宫内膜异位症患者核转录因子-κB及细胞间粘附分子-1的表达[J].南方医科大学学报,2005,(06):703.
 WANG Fang,HE Yuan-li,PENG Dong-xian,et al.Expressions of nuclear factor-kappaB and intercellular adhesion molecule-1 in endometriosis[J].,2005,(04):703.
[8]彭冬先,何援利,丘立文.慢病毒介导shRNA沉默survivin基因对鸡胚绒毛尿囊膜子宫内膜异位症模型的影响[J].南方医科大学学报,2012,(07):995.
[9]刘木彪,黄雪梅,许苏容,等.叶酸在预防胎源性子宫内膜异位症易感基因HOXA10异常甲基化中的作用[J].南方医科大学学报,2013,(06):926.
[10]侯震晖,全松,钱卫平,等.子宫内膜异位症患者体质量指数与体外受精—胚胎移植周期临床结局的关系[J].南方医科大学学报,2014,(03):379.

备注/Memo

备注/Memo:
收稿日期:2004-9-16。
作者简介:蔡珠华,女,工作单位:瑞安市人民医院,现为南方医科大学在读硕士,主要研究方向子宫内膜异位症的临床和基础研究,E-mail:caizhuhua12@hotmail.com
更新日期/Last Update: 1900-01-01