[1]邱学文,王甲汉,方小文,等.鸸鹋油对烫伤大鼠创面的抗炎及促愈合作用[J].南方医科大学学报,2005,(04):407-410.
 QIU Xue-wen,WANG Jia-han,FANG Xiao-wen,et al.Anti-inframnatory activity and healing-promoting effects of topical application of emu oil on wound in scalded rats[J].,2005,(04):407-410.
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鸸鹋油对烫伤大鼠创面的抗炎及促愈合作用()
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《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2005年04期
页码:
407-410
栏目:
出版日期:
2005-04-01

文章信息/Info

Title:
Anti-inframnatory activity and healing-promoting effects of topical application of emu oil on wound in scalded rats
作者:
邱学文1 王甲汉1 方小文2 龚震宇1 李志清1 易朝辉1
1. 南方医科大学南方医院烧伤科, 广东, 广州, 510515;
2. 广州英吉利实业有限公司, 广东, 广州, 510515
Author(s):
QIU Xue-wen1 WANG Jia-han1 FANG Xiao-wen2 GONG Zhen-yu1 LI Zhi-qing1 YI Zhao-hui1
1. Department of Burns, Nangfang Hospital, Southern Medical University, Guangzhou 510515, China;
2. Guangzhou Yingjili Co. Ltd, Guangzhou 510515, China
关键词:
烧伤鸸鹋油炎症创面创面愈合
Keywords:
burnsemu oilinflammation woundwound healing
分类号:
R644
摘要:
目的 从炎症反应的角度探讨外用鸸鹋油对烫伤大鼠创面愈合的影响。方法 建立10%体表面积浅Ⅱ度烫伤大鼠模型,将144只雄性Wistar大鼠随机分为A、B、C组,分别外用生理盐水、碘伏、鸸鹋油治疗,观察创面的大体变化及愈合情况,分别留取不同时相的创面和血液标本,进行组织病理学检查和含水量测定(干湿重法)、ELISA法检测组织和血浆TNFα含量。结果 外用鸸鹋油可使创面肿胀、渗出减轻,创面无感染迹象,未见任何副作用;病理形态学观察发现鸸鹋油可使局部组织炎症反应减轻,与A、B组相比较,以伤后1、3d差异最为明显;C组伤后3d组织含水量及TNF-α含量明显减少(P<0.01),两者之间存在正相关关系(P<0.001);可使创面愈合时间缩短(P<0.01),促进创面再上皮化和表皮各层的分化。结论 在浅Ⅱ度烫伤创面外用鸸鹋油具有抗炎作用,可能与局部组织中促炎细胞因子水平的降低有关;并能促进创面愈合,可能与其抑制局部组织的继发性炎症反应有关。
Abstract:
Objective To investigate the effects of topical application of emu oil on wound healing in scalded rats. Methods In 144 male Wistar rats with 10% total body surface superficial Ⅱ degree scald treated on a random basis with physiological saline, povidone iodine and emu oil, respectively, the changes of the wound were observed and the wound tissue and blood samples harvested at different times after injury for evaluation of histopathological changes, total tissue water content (measured by wet:dry weight ratios), and tumor necrosis factor (TNF)-α levels in the wound tissue and plasma by enzyme-linked immunosorbent assay (ELISA). The general condition of the wound healing was also observed. Results After application of emu oil, the swelling and effusion of the burn wound were alleviated and evidences of wound infection or adverse effects were not observed. Pathological examination showed that emu oil could alleviate topical inflammation, which was particularly obvious on days 1 and 3 after injury as compared with the other two groups. On day 3 after injury, water content and TNF-α level in the tissues was markedly decreased with the application of emu oil (P<0.05), with a significant correlation between their changes (P<0.001) and shortened wound healing time (P<0.05). Pathological examination showed that emu oil could promote epithelialization and differentiation of various epidermal layers. Conclusion Emu oil has topical anti-inflammatory activity in rats with superficial Ⅱ degree scald, possibly in association with decreased levels of the proinflammatory cytokines in the tissues and can promote wound healing by inhibiting local secondary inflammation.

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备注/Memo

备注/Memo:
收稿日期:2004-7-3。
基金项目:广东省自然科学基金重点项目(020089)
作者简介:邱学文(1978-),男,2004年毕业于第一军医大学,硕士,电话:020-61641888-87250,E-mail:shavin@sohu.com
更新日期/Last Update: 1900-01-01