[1]关美萍,李晨钟,薛耀明,等.2型糖尿病合并高血压病患者尿微量白蛋白患病率研究[J].南方医科大学学报,2005,(02):234-235.
 GUAN Mei-ping,LI Chen-zhong,XUE Yao-ming,et al.Prevalence of microalbuminuria in type 2 diabetic patients with hypertension[J].Journal of Southern Medical University,2005,(02):234-235.
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2型糖尿病合并高血压病患者尿微量白蛋白患病率研究()
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《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2005年02期
页码:
234-235
栏目:
出版日期:
2005-02-01

文章信息/Info

Title:
Prevalence of microalbuminuria in type 2 diabetic patients with hypertension
作者:
关美萍 李晨钟 薛耀明 沈洁 高方 罗祥容
南方医科大学南方医院内分泌科, 广东, 广州, 510515
Author(s):
GUAN Mei-ping LI Chen-zhong XUE Yao-ming SHEN Jie GAO Fang LUO Xiang-rong
Department of Endocrinology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
关键词:
糖尿病非胰岛素依赖型高血压微量白蛋白尿分析
Keywords:
diabetes mellitus non-insulin-dependenthypertensionmicroalbuminuriaurinalysis
分类号:
R544.1;R587.1
摘要:
目的 调查2型糖尿病合并高血压病患者的微量白蛋白尿患病率。方法 采用半定量比色尿试纸测定55例2型糖尿病合并高血压病患者的尿微量白蛋白,计算微量白蛋白尿的发生率。结果 2型糖尿病合并高血压病患者正常、微量及大量尿白蛋白的患病率分别为66.67%、22.22%和11.11%。结论 2型糖尿病合并高血压病患者中可能有约1/3的患者存在肾病损害,应早期筛查并干预治疗。
Abstract:
Objective To investigate the prevalence of microalbuminuria in type 2 diabetic patients with hypertension. Method Urinary albumin excretion was measured in 55 diabetic patients with hypertension by colorimetric methods using commercially available test strips of Nephur 7 and Micro-Ⅱ, the latter test strips employed only when the former yielded negative results for proteinuria. The height, body weight, waist circumference and blood pressure were measured for all the patients with also biochemical examination for serum total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, blood glucose and creatinine. HbA1c was determined by Bio-STAT. Results The rates of normal urinary albumin, micro-and macroalbuminuria were 66.67%, 22.22% and 11.11% in these patients, respectively. In patients with a history of diabetes for more than 10 years, the rates were 58.33%, 8.33% and 33.33%, respectively. Conclusion Nearly 1/3 of type 2 diabetic patients with hypertension have microalbuminuria and proteinuria, and screening for microalbuminuria and proper interventions in these patients might prove beneficial.

参考文献/References:

[1] Epstein M, Sowers JR. Diabetes mellitus and hypertension [J]. Hy pertension, 1992, 19(5): 403-18.
[2] Ravid M, Savin H, Jutrin I, et al. Long-term stabilizing effect of angiotensin converting enzyme inhibition on plasma creatinine and proteinuria in normotensive type Ⅱ diabetic patients [J]. Ann Int Med, 1993, 118(8): 577-81.
[3] Lebovitz HE, Wiegmann TB, Caan A, et al. Renal protective effects of enalapril in hypertensive NIDDM: role of baseline albuminuria [J]. Kidney Int Suppl, 1994, 45: S150-5.
[4] Keane W, Eknoyan G. Proteinuria, albuminuria, risk, assessment, detection, elimination(PARADE): a position paper of the National Kidney Foundation [J]. Am J Kidney Dis, 1999, 33(5): 1004-10.
[5] Savage S, Nagel NJ, Estacio RO, et al. Clinical factors associated with urinary albumin excretion in type Ⅱ diabetes[J]. Am J Kidney Dis, 1995, 25(6): 836-44.
[6] Cooper ME. Pathogenesis, prevention and treatment of diabetic nephropathy[J]. Lancet, 1998, 352(9123): 213-9.

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备注/Memo

备注/Memo:
收稿日期:2004-9-15。
作者简介:关美萍(1975- ),女,硕士,电话:020-61641888-87140
更新日期/Last Update: 1900-01-01