[1]王群,李永军,陆兵勋.甲状腺激素对慢性脑缺血大鼠认知功能障碍的改善作用[J].南方医科大学学报,2005,(01):106-108.
 WANG Qun,LI Yong-jun,LU Bing-xun.Effects of thyroid hormone on cognitive function in rats with chronic cerebral ischemia[J].,2005,(01):106-108.
点击复制

甲状腺激素对慢性脑缺血大鼠认知功能障碍的改善作用()
分享到:

《南方医科大学学报》[ISSN:/CN:]

卷:
期数:
2005年01期
页码:
106-108
栏目:
出版日期:
2005-01-01

文章信息/Info

Title:
Effects of thyroid hormone on cognitive function in rats with chronic cerebral ischemia
作者:
王群 李永军 陆兵勋
南方医科大学南方医院神经内科, 广东广州510515
Author(s):
WANG Qun LI Yong-jun LU Bing-xun
Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China
关键词:
甲状腺激素脑缺血认知
Keywords:
cerebral ischemiacognitionthyroid hormone
分类号:
Q572
摘要:
目的 研究慢性脑供血不足所致成年大鼠认知功能障碍的特点以及甲状腺激素对于认知功能的改善作用。方法 成年SD大鼠31只随机分为正常对照组12只;单纯手术组6只(双侧颈总动脉结扎术后5周);急性期给药组7只(双侧颈总动脉结扎术后当日始给予甲状腺激素灌胃,剂量20mg/只、频率1次/d、持续5周);慢性期给药组6只(双侧颈总动脉结扎术后第6周开始给予甲状腺激素灌胃,剂量20mg/只、频率1次/d、持续5周)。造模成功后用Morris水迷宫系统测试大鼠学习记忆能力。结果 定位航行实验单纯手术组之潜伏期较其他各组明显延长(P<0.05);空间探索实验正常组与单纯手术组、急性期给药组和慢性期给药组之间有差异(P<0.05);工作记忆正常组、急性期给药组与单纯手术组和慢性期给药组之间有显著差异(P<0.05),其中以单纯手术组成绩最差。结论 慢性脑供血不足导致成年大鼠空间认知功能全面障碍,其特点是以短期记忆能力受损为主,且不能通过学习形成新的长期记忆,甲状腺激素对于其认知功能障碍有防治作用,脑缺血早期用药效果更好。
Abstract:
Objective To study the characteristics of cognitive dysfunction in rats with chronic cerebral ischemia and the effects of thyroid hormone on the rats’ cognitive function. Methods Thirty-one male SD rats were randomly allocated into normal control group (n=12), operation group (with bilateral carotid artery ligation and examined 5 weeks later, n=6), acute phase treatment group (APT, with bilateral carotid artery ligation and intragastric administration of thyroid hormone at 20 mg once daily for 5 weeks starting from the day of operation, n=7) and chronic phase treatment group (CPT, with the operation and thyroid hormone administration in an identical manner started from the sixth week following the operation, n=6). Morris water maze test was performed at the end of experiment. One-way ANOVA was used to estimate the differences in the learning and memory functions of the rats using SPSS10.0 for Windows. Results The average latent period of the operation group was significantly prolonged in comparison with that of the other groups (P<0.05) in spatial orientation test. The probe time (time spent in the quadrant where the platform was once situated) of normal control was much shorter than those of the operation, APT and CPT groups in spatial probe test (P<0.05), and the operation group had the poorest score. The average latent period of the operation and CPT was longer than that of the other groups (P<0.05) in working-memory task (P<0.05), and the operation group again had the poorest score. Conclusion Spatial cognitive function is totally damaged in rats with chronic cerebral ischemia, and learning can not induce the formation long-term memory because of short-term memory damage. Thyroid hormone may lessen but can not fully repair the damage of the cognitive dysfunction resulting from chronic cerebral ischemia, and early intervention with thyroid hormone may be beneficial for chronic cerebral ischemia.

参考文献/References:

[1] Ichibangase A, Nishikawa M, Iwasaka T, et al. Relation between thyroid and cardiac functions and the geriatric rating scale [J]. Acta Neurol Scand, 1990, 81(6): 491-8.
[2] Morris R. Developments of a water-maze procedure for studying spatial learning in the rat[J]. J Neurosci Methods, 1984, 11: 47-60.
[3] Wickelgren I. Is hippocampal cell death a myth [J] ? Science, 1996,271(5253):1229-30.
[4] 赵宪林,房宝玉,方秀斌,等.血管性痴呆大鼠海马神经元凋亡的研究[J].中国医科大学学报,2000,29(4):264-6.Zhao XL, Fang BY, Fang XB, et al. Study on apoptosis of hippocampal neurons in rats with vascular dementia [J].J Chin Med Univ, 2000, 29(4):264-6.
[5] Wainwright PE, Xing HC, Ward GR, et al. Water maze performance is unaffected in artificially reared rats fed diets supplemented with arachidonic acid and docosahexaenoic acid [J]. J Nutr, 1999, 129(5): 1079-90.
[6] Goldman-Rakic PS. Cellular basis of working memory[J]. Neuron,1995, 14: 477-85.
[7] 王群,高晓,方忠耀.20例脑梗塞脑脊液甲状腺激素代谢初步研究[J].中国神经精神疾病杂志,1996,22(4):236-7.Wang Q, Gao X, Fang ZY, et al. The study on the metabolize of thyroid hormone in cerebrospinal fluid of the patients with cerebral infarction[J]. Chin J Nerv Ment Dis, 1996, 22(4): 236-7.
[8] 高义,蒲传强,王玉敏,等.老年人血管性痴呆与甲状腺轴功能关系的研究[J].中华老年医学杂志,2001,20(1):29-31.Gao Y, Pu CQ, Wang YM, et al. The relationship between vascular dementia and thyroid function in the elderly [J]. Chin J Geriatr,2001, 20(1):29-31.

相似文献/References:

[1]张兰兰,曹琼,胡子有,等.槲皮素对成年大鼠局灶性脑缺血后侧脑室室管膜下区神经干细胞增殖的影响[J].南方医科大学学报,2011,(07):1200.
[2]侯德仁,沙地克·沙吾提,刘建锋,等.意向运动疗法对大鼠局灶性脑缺血后GFAP和SYP表达的影响[J].南方医科大学学报,2011,(09):1543.
[3]尹瑞雪,陆兵勋,王立新,等.缺血再灌注损伤大鼠脑内神经巢蛋白的变化及通心络对它的影响[J].南方医科大学学报,2006,(06):777.
 YIN Rui-xue,LU Bing-xun,WANG Li-xin,et al.Nestin activation after rat cerebral ischemia-reperfusion injury and its changes in response to Tongxinluo treatment[J].,2006,(01):777.
[4]廖春来,佟丽,陈育尧.补阳还五汤对脑缺血大鼠nNOS免疫阳性神经元的影响[J].南方医科大学学报,2004,(08):864.
 LIAO Chun-lai,0TONG Li,CHEN Yu-yao.Effect of Buyanghuanwu decoction on neuronal nitric oxide synthase expression after permanent focal cerebral ischemia in rats[J].,2004,(01):864.
[5]朱心红,杨建明,高天明.脑心通对大鼠脑缺血海马CA1区神经元损伤的保护作用[J].南方医科大学学报,2004,(10):1123.
 ZHU Xin-hong,YANG Jian-ming,GAO Tian-ming.Neuroprotective effects of Naoxintong against neuronal injury in hippocampal CA1 region following transient forebrain ischemia in rats[J].,2004,(01):1123.
[6]崔丹,管玉青,蒋海山,等.甲状腺激素转运体MCT8 在2VO大鼠脑组织中的表达[J].南方医科大学学报,2012,(06):913.
[7]席蕾,汪槿,郑卉,等.甲状腺激素对慢性脑缺血大鼠海马细胞的保护作用和机制[J].南方医科大学学报,2013,(05):765.
[8]王楠,商博鑫,史海涛,等.甲状腺激素可抑制人胰腺癌裸鼠移植瘤的生长[J].南方医科大学学报,2013,(08):1160.
[9]黄丽,王春,李言,等.针刺预处理对脑缺血大鼠小脑浦肯野细胞动作电位的影响[J].南方医科大学学报,2018,(06):677.

备注/Memo

备注/Memo:
收稿日期:2004-7-10。
作者简介:王群(1962- ),女,1983年毕业于第一军医大学,硕士,副教授,副主任医师,E-mail:zhpn@fimmu.com
更新日期/Last Update: 1900-01-01