[1]黄运生,谢炜,陈宝田.柴胡皂甙对癫痫大鼠脑电的影响[J].南方医科大学学报,2004,(12):1379-1381.
 HUANG Yun-sheng,XIE Wei,CHEN Bao-tian.Effect of saikosaponins on epileptic rat electroenciphalogram[J].Journal of Southern Medical University,2004,(12):1379-1381.
点击复制

柴胡皂甙对癫痫大鼠脑电的影响()
分享到:

《南方医科大学学报》[ISSN:1673-4254/CN:44-1627/R]

卷:
期数:
2004年12期
页码:
1379-1381
栏目:
出版日期:
2004-12-01

文章信息/Info

Title:
Effect of saikosaponins on epileptic rat electroenciphalogram
作者:
黄运生 谢炜 陈宝田
南方医科大学中医系, 广东, 广州, 510515
Author(s):
HUANG Yun-sheng XIE Wei CHEN Bao-tian
Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou 510515, China
关键词:
癫痫柴胡皂甙拉莫三嗪脑电图
Keywords:
epilepsysaikosaponinslamotrignieelectroencephalogram
分类号:
R285.5
摘要:
目的 观察柴胡皂甙对癫痫大鼠脑电的影响,探讨柴胡皂甙抗癫痫作用。方法 用8周龄健康SD大鼠,随机分为6组,正常对照组(A)、癫痫模型组(B)、拉莫三嗪组(C)、柴胡皂甙小剂量组(D)、柴胡皂甙中剂量组(E)和柴胡皂甙大剂量组(F),每组10只。后5组动物用青霉素致痫,在成功造模及用药物治疗后,分别检测脑电图和观察痫性发作行为。结果 A组脑电图正常,B组脑电图显示明显癫痫放电,C组和F组癫痫大鼠脑电图恢复正常,D组大鼠脑电图有少量癫痫放电,E组大鼠脑电图基本恢复正常。C、D、E、F组与B组脑电图相比较有显著性差异(P<0.001)。结论 柴胡皂甙对癫痫大鼠脑电图及痫性发作有明显改善作用。
Abstract:
Objective To study the effect of saikosaponins on the electroencephalogram (EEG) of epileptic rats to evaluate its therapeutic effect against epilepsies. Methods Sixty 8-week-old healthy SD rats were randomized into normal control group (A), epileptic model group (B), lamotrigine group (C), and 3 saikosaponin groups of small, moderate and high doses (D, E, and F groups, respectively), with 10 rats in each group. Penicillin was used to induce epilepsy in the latter 5 groups, and the EEG and onset of epileptic seizures were observed in each group. Results In group B, the EEG contained obvious epileptic discharges, which were not found in that in group A. After treatment with saikosaponins and lamotrignie, the EEG of group C and F became normal, whereas the EEG in group D still contained epileptic discharges at a low level, and that in group E was basically normal. The EEGs of group C, D, E, and F were significantly different from that in group B (P<0.001). Conclusion Saikosaponins can obviously alleviate the severity of epileptic seizure in epileptic rats.

参考文献/References:

[1] 蒙桂珍,徐燎原,戴京萍.柴胡颗粒剂治疗原发性癫痫的疗效观察[J].海军医学杂志,2000,21(2):157-9.Meng GZ, Xu LY, Dai JP. Observation of the therapeutic effect of Bupleurum root granule on primary epilepsy[J]. J Navy Med, 2000,21(2): 157-9.
[2] 邹晓毅,阮旭中,周树舜,等.尼莫地平对青霉素诱导的鼠癫痫的抑制作用的观察[J].华西医科大学学报(J West China Univ Med Sci),1997,28(4):383-7
[3] 刘智良,徐如祥,张新伟.点燃效应癫痫动物模型研究状况及评价[J].第一军医大学学报(JFirstMilMedUniv/DiYi JunYiDa Xue Xue Bao),2001,21(8):621-3.
[4] 魏泓.医学实验动物学[M].成都:四川科学技术出版社,1998.263-8
[5] 李萍,傅春华.北柴胡与三岛柴胡药材及成分研究[J].成都中医药大学学报(J Chengdu Univ TCM),1997,20(2):46-7
[6] Binne CD. The efficacy of Lamotrigine[J]. Rev Contemp Pharmacother, 1994, 5: 115.
[7] Besag MC. Lamortrigine in the management of subtle seizures [J].Rev Contemp Pharmacother, 1994, 5: 123.
[8] 李白中.关于柴胡药理研究的探讨[J].中药通报(Bull Chin MaterMed),1983,8(2):39.
[9] 徐如祥.中国癫痫外科的临床和基础研究进展[J].第一军医大学学报,2003,23(7):649-51.Xu RX.Progressin clinical and basic research ofepilepsyin China[J].J First Mil Med Univ/Di Yi Jun Yi Da Xue Xue Bao,2003,23(7):649-51.
[10] 周秋丽,张志强,长泽哲郎,等.柴胡皂甙抑制Na+、K+-ATP酶活性的构效关系[J].白求恩医科大学学报(J N Bethune Univ Med Sci),1997,23(4):356-8

相似文献/References:

[1]张庆平,卢广文.癫痫多导脑电非线性分析[J].南方医科大学学报,2005,(03):345.
 ZHANG Qing-ping,LU Guang-wen.Nonlinear analysis of epileptic multichannel EEG[J].Journal of Southern Medical University,2005,(12):345.
[2]孙素真,王铭维,冯宗怀,等.儿童特发性癫痫与睡眠结构的关系[J].南方医科大学学报,2005,(03):354.
 SUN Su-zhen,WANG Ming-wei,FENG Zong-huai,et al.Relationship between idiopathic epilepsy and sleep macrostructure in children[J].Journal of Southern Medical University,2005,(12):354.
[3]漆松涛,邱炳辉,欧阳辉,等.创伤性癫痫的临床特征及外科治疗[J].南方医科大学学报,2004,(04):472.
 QI Song-tao,QIU Bing-hui,OUYANG Hui,et al.Clinical features and surgical treatment of posttraumatic epilepsy[J].Journal of Southern Medical University,2004,(12):472.
[4]陈永平,谢运兰,王衡,等.SIRT1在癫痫患者及大鼠脑组织中的表达与活性[J].南方医科大学学报,2013,(04):528.

备注/Memo

备注/Memo:
收稿日期:2004-4-16。
基金项目:广东省中医药管理局立项课题(401001);
作者简介:黄运生(1971- ),男,1995年毕业于南方医科大学,主治医师,南方医科大学中医系中医内科在读博士研究生,电话:020-61365732,E-mail:hnhys2002@yahoo.com.cn
更新日期/Last Update: 1900-01-01